Magnetic Resonance Measurement of Heart and Liver Iron

心脏和肝脏铁的磁共振测量

• 批准号: 7095257
• 负责人: Gary M Brittenham
• 金额: $ 39.91万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7095257
• 关键词: bioimaging /biomedical imaging; clinical research; ferritin; heart; human subject; interview; iron; iron metabolism; liver; magnetic resonance imaging; method development

DESCRIPTION (provided by applicant): The proposed research will integrate radiological, clinical and laboratory efforts in the development and validation of quantitative magnetic resonance methods for the measurement of heart and liver iron. We propose to acquire a fundamental theoretical and physical understanding of the resonance effects of tissue iron as a guide in the development of novel MR techniques that will provide clinically applicable methods for the quantitative measurement of hepatic and cardiac iron. These studies will take advantage of a unique convergence of resources and expertise at Columbia University, including the Hatch MR Research Center, active programs of liver and heart transplantation, the Iron Reference Laboratory, and the SQUID biosusceptometry facility where hundreds of patients with diverse forms of iron overload are seen each year. The proposed research has three specific aims: (1) to investigate systematically in and ex vivo the resonance behavior of ferritin and hemosiderin iron in diverse hepatic and cardiac disorders in patients undergoing organ transplantation, using candidate MR methods including conventional spin- and gradient-echo sequences, spectroscopic techniques, and projection reconstruction-based pulse sequences designed to facilitate capture of short T2* components; and ( 2 ) to examine selected MR methods for measurement of hepatic and cardiac iron in patients with iron overload of diverse severity and etiologies (hereditary hemochromatosis, chronic transfusion for thalassmia major, sickle cell disease, aplastic and other refractory anemia) in conjunction with SQUID biosusceptometry in vivo, magnetic susceptometry ex vivo, ultrastructural and biochemical studies of explant tissue; and (3) to prospectively validate optimized MR measurements of hepatic and cardiac iron concentrations with the results of biochemical analysis of tissue from heart and liver explants in series of adult and pediatric patients with and without disorders affecting iron metabolism. The development of validated, clinically applicable MR methods for the non-invasive measurement of hepatic and cardiac iron would be a major advance in the diagnosis and management of patients with iron overload that would find immediate and widespread diagnostic use both in the U.S. and worldwide.

描述（由申请人提供）： 拟议的研究将整合放射学、临床和实验室的努力，开发和验证用于测量心脏和肝脏铁的定量磁共振方法。我们建议对组织铁的共振效应有一个基本的理论和物理理解，作为开发新型磁共振技术的指南，该技术将为肝脏和心脏铁的定量测量提供临床适用的方法。这些研究将利用哥伦比亚大学独特的资源和专业知识融合，包括 Hatch MR 研究中心、肝脏和心脏移植的活跃项目、铁参比实验室和 SQUID 生物电阻测量设施，每年都会看到数百名患有不同形式铁超载的患者。拟议的研究有三个具体目标：（1）系统地研究铁蛋白和含铁血黄素铁在接受器官移植的患者的多种肝脏和心脏疾病中的体内和离体共振行为，使用候选MR方法，包括传统的自旋和梯度回波序列、光谱技术和旨在促进短T2*成分捕获的基于投影重建的脉冲序列； (2) 结合 SQUID 体内生物电感受器、离体磁感受器、超微结构和生化技术，检查选定的 MR 方法，用于测量不同严重程度和病因的铁超负荷患者（遗传性血色素沉着病、重型地中海贫血、镰状细胞病、再生障碍性贫血和其他难治性贫血）患者的肝脏和心脏铁含量 外植体组织的研究； (3) 利用一系列患有或不患有影响铁代谢疾病的成人和儿童患者的心脏和肝脏外植体组织的生化分析结果，前瞻性地验证肝脏和心脏铁浓度的优化 MR 测量结果。开发经过验证的、临床适用的 MR 方法，用于非侵入性测量肝脏和心脏的铁，将是铁过载患者诊断和治疗方面的重大进步，将在美国和全世界立即广泛用于诊断。

项目成果

Rapid monitoring of iron-chelating therapy in thalassemia major by a new cardiovascular MR measure: the reduced transverse relaxation rate.

通过一种新的心血管 MR 测量方法快速监测重型地中海贫血的铁螯合疗法：横向弛豫率降低。

• DOI: 10.1002/nbm.1639
• 发表时间: 2011
• 期刊: NMR in biomedicine
• 影响因子: 2.9
• 作者: Kim,Daniel;Jensen,JensH;Wu,EdX;Feng,Li;Au,Wing-Yan;Cheung,JerryS;Ha,Shau-Yin;Sheth,SujitS;Brittenham,GaryM
• 通讯作者: Brittenham,GaryM

Iron-chelating therapy for transfusional iron overload.

• DOI: 10.1056/nejmct1004810
• 发表时间: 2011-01-13
• 期刊: The New England journal of medicine
• 作者: Brittenham GM