Sun Exposure and Melanoma in Agricultural Workers

农业工人的阳光照射与黑色素瘤

• 批准号: 7064874
• 负责人: LESLIE K DENNIS
• 金额: $ 13.6万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7064874
• 关键词: Sun; Exposure; Melanoma; Agricultural; Workers

DESCRIPTION (provided by applicant): This K07 Career Development Award application is designed to expand my career development from cancer etiology to cancer prevention and control. The career development plan rests on mentoring directed by experts in cancer prevention research and "protected time" to foster my professional development as an independent cancer control researcher. While I have training and expertise in epidemiology and biostatistics, it is becoming clear that my career development requires more specific exposure to behavioral research methodologies and behavioral intervention techniques. A unique population, the Agricultural Health Study (AHS) cohort, will be used to examine sun exposure, sun protection behavior, and factors affecting these behaviors regarding the risk of melanoma in private pesticide applicators (farmers) and their spouses. This career development program integrates my statistical and epidemiologic expertise for analyzing existing data in Year 1, with Behavioral Health education to develop my skills in measurement of factors affecting behavior and skills to design and conduct behavioral interventions. In Year 1, I will take courses and spend 2 weeks at the National Cancer Institute learning more about the Agricultural Health Study (AHS) and its measurement of environmental exposures under my co-mentor Dr. Michael Alavanja to guide my analysis of existing baseline data on the cohort related to melanoma. I will then work with my mentor Dr. John Lowe at the University of Iowa during Years 2-5 to expand my survey skills to conducting focus groups, examining behavioral factors, and behavioral attitudes, and develop skills in behavioral interventions. The research plan proposes to examine skin melanoma within this prospective cohort of private applicators (mostly farmers) and their spouses in Iowa and North Carolina (the AHS) in association with environmental factors. The specific aims are as follows: Aim 1 is to examine the risk of melanoma in the AHS cohort using various existing measures of sun exposure adjusted for skin sensitivity and sun protection. Aim 2 is to conduct qualitative research using focus groups to design appropriate measures of sun exposure, sun protection behavior, and factors affecting these behaviors in private applicators and their spouses within the AHS. Aim 3 is to conduct a nested case-control study of melanoma within the AHS cohort to examine in more detail sun exposure histories and protective behavior. Aim 4 is to use the results from the cohort and nested case-control studies to design a behavioral intervention. These aims will lead to the development of a R01 proposal to a) survey the whole AHS cohort about sun exposure, and to b) conduct a behavioral intervention as an independent cancer control researcher.

描述(申请人提供)：本次K07职业发展奖申请旨在将我的职业发展从癌症病因学扩展到癌症预防和控制。职业发展计划依赖于癌症预防研究专家的指导和“保护时间”，以促进我作为一名独立癌症控制研究人员的专业发展。虽然我有流行病学和生物统计学方面的培训和专业知识，但越来越明显的是，我的职业发展需要更具体的行为研究方法和行为干预技术。一个独特的人群，农业健康研究(AHS)队列，将被用来检查阳光暴露、防晒行为，以及影响私人农药施用者(农民)及其配偶患黑色素瘤风险的这些行为的因素。这一职业发展计划将我在第一年分析现有数据的统计和流行病学专业知识与行为健康教育相结合，以发展我在衡量影响行为的因素方面的技能，以及设计和实施行为干预的技能。在第一年，我将参加课程，在国家癌症研究所呆上两周，在我的共同导师Michael Alavanja博士的指导下，学习更多关于农业健康研究(AHS)及其对环境暴露的测量，以指导我对与黑色素瘤相关的队列的现有基线数据的分析。然后，我将在2-5年内与我在爱荷华大学的导师John Lowe博士合作，将我的调查技能扩展到领导焦点小组，检查行为因素和行为态度，并发展行为干预技能。 该研究计划建议在爱荷华州和北卡罗来纳州(AHS)的私人申请者(主要是农民)及其配偶(AHS)的预期队列中检查与环境因素有关的皮肤黑色素瘤。具体目标如下：目标1是使用根据皮肤敏感度和防晒措施调整的各种现有日晒措施，检查AHS队列中黑色素瘤的风险。目标2是利用焦点小组进行定性研究，以设计适当的措施来衡量AHS中的私人涂药者及其配偶的日晒、防晒行为以及影响这些行为的因素。目标3是对AHS队列中的黑色素瘤进行嵌套病例对照研究，以更详细地检查阳光暴露史和防护行为。目标4是使用队列和嵌套病例对照研究的结果来设计行为干预。 这些目标将导致R01提案的发展，a)调查整个AHS队列中关于阳光暴露的情况，以及b)作为独立的癌症控制研究人员进行行为干预。