Downstream processes that occur in AT1s following the exposure to microplastics in context to ambient air pollution

AT1 因环境空气污染而暴露于微塑料后发生的下游过程

• 批准号: 2749385
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2749385
• 关键词: Downstream; processes; occur; AT1s; following

The aim is to better understand the downstream processes that occur in AT1s following the exposure to microplastics in context to ambient air pollution.This study will have three separate aims that will tackle this objective from different angles to provide an overview of the cellular responses to airborne pollution. The aims are the following 1. Investigate the mechanisms by which microplastics independently or as a part of the mixture enter the alveolar epithelial cells; 2. Examine the transcriptome, metabolome, and proteome of AT1 cells following to the exposure microplastics independently or as a part of the mixture enter the alveolar epithelial cells and 3. (potentially) Set up 3D cell model that represents the lung microenvironment and expose it to microplastics independently and as a part of mixture (with PM2.5) to determine how cells respond.

其目的是更好地了解在环境空气污染中暴露于微塑料后AT1中发生的下游过程。这项研究将有三个不同的目标，将从不同的角度解决这一目标，以提供对空气污染的细胞反应的概述。研究的目的如下：1.研究微塑料单独或作为混合物进入肺泡上皮细胞的机制；2.检测单独或作为混合物进入肺泡上皮细胞后AT1细胞的转录组、代谢组和蛋白质组；3.(可能)建立代表肺微环境的三维细胞模型，并将其单独和作为混合物(与PM2.5)接触以确定细胞的反应。