Anosteocytic bone remodelling as a potential evolutionary biomimetic route for tissue engineering

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Bone fractures are a public health issue around the world and pose a serious economic burden, and are expected to increase with an ageing population and the increased prevalence of associated disorders such as osteoporosis. Tissue engineering has been tackling this issue from different angles, building on our natural capability to regenerate bone. Regenerative medicine could benefit from exploration of emerging mechanisms that might be stimulated to induce bone reconstruction, adopting an evolutionary biomimetic strategy.