Multi-scale models for the prediction of bone remodelling due to musculoskeletal interventions

用于预测肌肉骨骼干预引起的骨重塑的多尺度模型

• 批准号: 2458972
• 金额: --
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2458972
• 关键词: Multi; scale; models; prediction; bone

The hypothesis of this project is that multi-scale computational models can accurately predict bone changes over time due to osteoporosis and related interventions. The project aims at developing the first multi-scale biomechanical model for the prediction of bone changes over time in the mouse tibia due to external biomechanical and biochemical stimuli, and at validating its outcomes versus state-of-the-art longitudinal micro-computed tomography (microCT) measurements of bone changes

该项目的假设是，多尺度计算模型可以准确预测骨质疏松症和相关干预措施引起的骨变化。该项目旨在开发第一个多尺度生物力学模型，用于预测由于外部生物力学和生物化学刺激而导致的小鼠胫骨随时间的骨变化，并验证其结果与最先进的骨变化纵向微计算机断层扫描（microCT）测量结果