Furin: Carving-up vital substrates for bone remodelling and homeostasis

弗林蛋白酶：分解骨重塑和体内平衡的重要底物

• 批准号: nhmrc : GNT1107828
• 负责人: A/Pr Nathan Pavlos
• 金额: $ 81.6万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/furin-carving-up-remodelling-homeostasis/1346607
• 关键词: Furin; Carving; up; vital; substrates

Osteoporosis, or porous bone, is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased susceptibility to fractures. It is caused by an imbalance between the cells that are constantly reabsorbing and reforming bone. The proposed project will address furin as a novel regulator of bone remodelling.

骨质疏松症，或称多孔骨，是一种以骨量减少和骨组织结构恶化为特征的疾病，导致骨骼脆性和骨折易感性增加。它是由不断重新吸收和改造骨骼的细胞之间的失衡造成的。拟议的项目将致力于将呋喃作为一种新的骨重塑调节器。