The Early Detection Research Network: Biomarker Referen*

早期检测研究网络：生物标志物参考*

• 批准号: 6941527
• 负责人: DAVID S. CHIA
• 金额: $ 61.39万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-16 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941527
• 关键词: biomarker; cancer registry /resource; carcinogenesis; chromosome aberrations; clinical research; cytogenetics; enzyme linked immunosorbent assay; flow cytometry; gene expression; genetic polymorphism; high throughput technology; human subject; immunocytochemistry; in situ hybridization; microarray technology; neoplasm /cancer genetics; tissue resource /registry; tumor antigens; western blottings

DESCRIPTION (provided by applicant): The UCLA Biomarker Reference Laboratory (UCLA-BRL) is designed to be a continuation and expansion of the established EDRN-funded UCLA Biomarker Validation Laboratory (BVL). Significantly, the UCLA BVL is highly successful having established numerous EDRN collaborations and constructed tissue microarray resources for EDRN investigators. Our goals are in close alignment with the mission of the EDRN and include: i) The utilization our diverse infrastructure and highly skilled personnel to test, evaluate, quantify, and optimize detection of biomarkers useful early stage tumor marker. To this end, we have established Scientific Centers that can test for biomarkers in tissue (full tissue sections or 'intelligent' high density tissue microarrays) and in fluids (by conventional ELISA and nanotech electrochemical chip). In addition, we have the resources to detect nucleic acids in body fluids as well as DNA modification and alterations in tissue, cells and/or fluids. ii) The development of new platforms and algorithms for biomarker detection and analysis. This includes the development and implementation, in conjunction with an industrial partner, of a high throughput nano-detection chip for measuring biomarkers in fluids, and in-house pioneering research on mining biomarker profiles using tissue microarrays. iii) The continuation of a program at UCLA that is highly professional and focused, yet at the same time flexible and cost-effective in order to meet the challenges of an evolving EDRN program. iv) A strong commitment to collaboration, teamwork, and sharing of resources and data with EDRN members in order to promote the goal of identifying clinically useful early detection biomarkers. The UCLA-BRL leadership is highly capable and enthusiastic, and strongly dedicated to the goals of the EDRN. Moreover, the UCLA-BRL has strong institutional support from the School of Medicine, Jonsson Comprehensive Cancer Center, the UCLA Lung Cancer SPORE, and the UCLA Prostate Cancer SPORE.

描述(由申请人提供)：加州大学洛杉矶分校生物标记物参考实验室(UCLA-BRL)是由EDRN资助的加州大学洛杉矶分校生物标记物验证实验室(BVL)的延续和扩展。值得注意的是，加州大学洛杉矶分校的BVL非常成功，建立了许多EDRN合作，并为EDRN研究人员构建了组织微阵列资源。我们的目标与EDRN的使命密切一致，包括：i)利用我们多样化的基础设施和高技能的人员来测试、评估、量化和优化生物标记物的检测，这些生物标记物是有用的早期肿瘤标记物。为此，我们建立了科学中心，可以测试组织(完整组织切片或“智能”高密度组织微阵列)和液体(通过传统的酶联免疫吸附试验和纳米技术电化学芯片)中的生物标志物。此外，我们有资源检测体液中的核酸以及组织、细胞和/或体液中的DNA修饰和改变。二)开发生物标记物检测和分析的新平台和新算法。这包括与一家工业合作伙伴合作开发和实施用于测量流体中生物标记物的高通量纳米检测芯片，以及内部利用组织微阵列挖掘生物标记物轮廓的开创性研究。3)在加州大学洛杉矶分校继续实施一项高度专业和重点突出的计划，同时又要灵活和具有成本效益，以应对不断发展的EDRN计划所带来的挑战。Iv)坚定地致力于与EDRN成员合作、团队合作和共享资源和数据，以促进确定临床上有用的早期检测生物标志物的目标。加州大学洛杉矶分校-BRL的领导层非常有能力和热情，并强烈致力于EDRN的目标。此外，加州大学洛杉矶分校-BRL得到了医学院、琼森综合癌症中心、加州大学洛杉矶分校肺癌孢子和加州大学洛杉矶分校前列腺癌分生孢子的大力机构支持。