The Early Detection Research Network Biomarker Resource Laboratory at UCLA

描述（由申请人提供）：UCLA生物标志物参考实验室（UCLA BRL）旨在延续和扩展已建立的EDRN资助的UCLA BRL。值得注意的是，UCLA BRL已经非常成功地建立了许多EDRN合作，并为EDRN研究人员构建和成功利用了组织微阵列资源。我们的目标与EDRN的使命密切相关，包括：i）利用我们多样化和广泛的基础设施和高技能人员来测试、评估、量化、验证和优化有用的早期肿瘤标志物生物标志物的检测。为此，我们建立了科学中心，可以测试组织和/或液体中的蛋白质和/或核酸生物标志物。为此，科学中心在组织分析性能和开发方面拥有丰富的经验和专业知识（全组织切片或“智能高密度组织微阵列”）、蛋白质（包括常规和高通量蛋白质组学），和核酸（包括表达谱、DNA修饰或突变、染色体异常和/或microRNA谱），ii）这包括一个开发计划，重点是利用高密度组织微阵列结合新的数据挖掘工具套件来定义临床上有用的肿瘤标志物，iii）继续加州大学洛杉矶分校的一个高度专业和集中的计划，但同时又灵活和具有成本效益，以应对不断发展的EDRN计划的挑战，iv）坚定地致力于与EDRN成员合作、团队合作以及共享资源和数据，以促进鉴定临床上有用的肿瘤生物标志物的目标。UCLA BRL的领导层非常有能力和热情，并强烈致力于EDRN的目标。此外，UCLA-BRL还得到了医学院，Jonsson综合癌症中心，UCLA肺癌计划和UCLA前列腺癌SPORE的强大机构支持。

DESCRIPTION (provided by applicant): The UCLA Biomarker Reference Laboratory (UCLA BRL) is designed to be a continuation and expansion of the established EDRN-funded UCLA BRL. Significantly, the UCLA BRL has been highly successful having established numerous EDRN collaborations and constructed and successfully utilized tissue microarray resources for EDRN investigators. Our goals are in close alignment with the mission of the EDRN and include: i) the utilization of our diverse and extensive infrastructure and highly skilled personnel to test, evaluate, quantify, validate and optimize detection of biomarkers useful early stage tumor marker. To this end, we have established Scientific Centers that can test for biomarkers which are protein and/or nucleic acid in nature in tissue and/or in fluids. To this end, the Scientific Centers have extensive experience and expertise in assay performance and development for tissues (full tissue sections or 'intelligent high-density tissue microarrays), proteins (including conventional and high-throughput protemics), and nucleic acids (including expression profiles, DNA modifications or mutations, chromosomal abnormalities, and/or microRNA profiles), ii) This includes a developmental program focused on defining clinically useful tumor markers utilizing high density tissue microarray combined with a novel data-mining tool suite, iii) The continuation of a program at UCLA that is highly professional and focused, yet at the same time flexible and cost-effective in order to meet the challenges of an evolving EDRN program, iv) A strong commitment to collaboration, teamwork, and sharing of resources and data with EDRN members in order to promote the goal of identifying clinically useful tumor biomarkers. The UCLA BRL leadership is highly capable and enthusiastic, and strongly dedicated to the goals of the EDRN. Moreover, the UCLA-BRL has strong institutional support from the School of Medicine, Jonsson Comprehensive Cancer Center, the UCLA Lung Cancer Program, and the UCLA Prostate Cancer SPORE.