The Early Detection Research Network Biomarker Resource Laboratory at UCLA

描述（由申请人提供）：加州大学洛杉矶分校生物标志物参考实验室 (UCLA BRL) 旨在成为 EDRN 资助的已建立的 UCLA BRL 的延续和扩展。值得注意的是，加州大学洛杉矶分校 BRL 取得了巨大成功，建立了众多 EDRN 合作关系，并为 EDRN 研究人员构建并成功利用了组织微阵列资源。我们的目标与 EDRN 的使命密切相关，包括：i) 利用我们多样化且广泛的基础设施和高技能人员来测试、评估、量化、验证和优化有用的早期肿瘤标志物的生物标志物检测。为此，我们建立了科学中心，可以测试组织和/或体液中本质上是蛋白质和/或核酸的生物标志物。为此，科学中心在组织（全组织切片或“智能高密度组织微阵列”）、蛋白质（包括常规和高通量蛋白质组）和核酸（包括表达谱、DNA修饰或突变、染色体异常和/或微RNA谱）的检测性能和开发方面拥有丰富的经验和专业知识，ii）这包括一个开发计划，重点是利用高密度组织微阵列结合新型数据挖掘工具套件来定义临床上有用的肿瘤标志物， iii) 继续在加州大学洛杉矶分校开展一项高度专业和专注的项目，同时灵活且具有成本效益，以应对不断发展的 EDRN 项目的挑战，iv) 坚定致力于与 EDRN 成员合作、团队合作以及共享资源和数据，以促进识别临床上有用的肿瘤生物标志物的目标。 UCLA BRL 领导层能力出众、热情高涨，并致力于实现 EDRN 的目标。此外，UCLA-BRL 还得到了医学院、Jonsson 综合癌症中心、UCLA 肺癌项目和 UCLA 前列腺癌 SPORE 的强大机构支持。

DESCRIPTION (provided by applicant): The UCLA Biomarker Reference Laboratory (UCLA BRL) is designed to be a continuation and expansion of the established EDRN-funded UCLA BRL. Significantly, the UCLA BRL has been highly successful having established numerous EDRN collaborations and constructed and successfully utilized tissue microarray resources for EDRN investigators. Our goals are in close alignment with the mission of the EDRN and include: i) the utilization of our diverse and extensive infrastructure and highly skilled personnel to test, evaluate, quantify, validate and optimize detection of biomarkers useful early stage tumor marker. To this end, we have established Scientific Centers that can test for biomarkers which are protein and/or nucleic acid in nature in tissue and/or in fluids. To this end, the Scientific Centers have extensive experience and expertise in assay performance and development for tissues (full tissue sections or 'intelligent high-density tissue microarrays), proteins (including conventional and high-throughput protemics), and nucleic acids (including expression profiles, DNA modifications or mutations, chromosomal abnormalities, and/or microRNA profiles), ii) This includes a developmental program focused on defining clinically useful tumor markers utilizing high density tissue microarray combined with a novel data-mining tool suite, iii) The continuation of a program at UCLA that is highly professional and focused, yet at the same time flexible and cost-effective in order to meet the challenges of an evolving EDRN program, iv) A strong commitment to collaboration, teamwork, and sharing of resources and data with EDRN members in order to promote the goal of identifying clinically useful tumor biomarkers. The UCLA BRL leadership is highly capable and enthusiastic, and strongly dedicated to the goals of the EDRN. Moreover, the UCLA-BRL has strong institutional support from the School of Medicine, Jonsson Comprehensive Cancer Center, the UCLA Lung Cancer Program, and the UCLA Prostate Cancer SPORE.