The Early Detection Research Network: Biomarker Referen*

早期检测研究网络：生物标志物参考*

• 批准号: 7103659
• 负责人: DAVID S. CHIA
• 金额: $ 13.33万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-16 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7103659
• 关键词: biomarker; cancer registry /resource; carcinogenesis; chromosome aberrations; clinical research; cytogenetics; enzyme linked immunosorbent assay; flow cytometry; gene expression; genetic polymorphism; high throughput technology; human subject; immunocytochemistry; in situ hybridization; microarray technology; neoplasm /cancer genetics; tissue resource /registry; tumor antigens; western blottings

DESCRIPTION (provided by applicant): The UCLA Biomarker Reference Laboratory (UCLA-BRL) is designed to be a continuation and expansion of the established EDRN-funded UCLA Biomarker Validation Laboratory (BVL). Significantly, the UCLA BVL is highly successful having established numerous EDRN collaborations and constructed tissue microarray resources for EDRN investigators. Our goals are in close alignment with the mission of the EDRN and include: i) The utilization our diverse infrastructure and highly skilled personnel to test, evaluate, quantify, and optimize detection of biomarkers useful early stage tumor marker. To this end, we have established Scientific Centers that can test for biomarkers in tissue (full tissue sections or 'intelligent' high density tissue microarrays) and in fluids (by conventional ELISA and nanotech electrochemical chip). In addition, we have the resources to detect nucleic acids in body fluids as well as DNA modification and alterations in tissue, cells and/or fluids. ii) The development of new platforms and algorithms for biomarker detection and analysis. This includes the development and implementation, in conjunction with an industrial partner, of a high throughput nano-detection chip for measuring biomarkers in fluids, and in-house pioneering research on mining biomarker profiles using tissue microarrays. iii) The continuation of a program at UCLA that is highly professional and focused, yet at the same time flexible and cost-effective in order to meet the challenges of an evolving EDRN program. iv) A strong commitment to collaboration, teamwork, and sharing of resources and data with EDRN members in order to promote the goal of identifying clinically useful early detection biomarkers. The UCLA-BRL leadership is highly capable and enthusiastic, and strongly dedicated to the goals of the EDRN. Moreover, the UCLA-BRL has strong institutional support from the School of Medicine, Jonsson Comprehensive Cancer Center, the UCLA Lung Cancer SPORE, and the UCLA Prostate Cancer SPORE.

描述（由申请人提供）：加州大学洛杉矶分校生物标志物参考实验室（UCLA- brl）旨在成为edrn资助的加州大学洛杉矶分校生物标志物验证实验室（BVL）的延续和扩展。值得注意的是，加州大学洛杉矶分校BVL非常成功地建立了许多EDRN合作，并为EDRN研究人员构建了组织微阵列资源。我们的目标与EDRN的使命密切相关，包括：i)利用我们多样化的基础设施和高技能的人员来测试、评估、量化和优化对早期肿瘤标志物有用的生物标志物的检测。为此，我们建立了科学中心，可以测试组织（全组织切片或“智能”高密度组织微阵列）和液体（通过传统的ELISA和纳米技术电化学芯片）中的生物标志物。此外，我们还拥有检测体液中的核酸以及组织、细胞和/或液体中的DNA修饰和改变的资源。ii)开发用于生物标志物检测和分析的新平台和算法。这包括与工业合作伙伴共同开发和实施用于测量流体中生物标志物的高通量纳米检测芯片，以及使用组织微阵列挖掘生物标志物剖面的内部开创性研究。iii)为了应对不断发展的EDRN项目的挑战，继续在加州大学洛杉矶分校开设一个高度专业和专注的项目，同时保持灵活性和成本效益。iv)致力于与EDRN成员合作，团队合作，共享资源和数据，以促进确定临床有用的早期检测生物标志物的目标。UCLA-BRL的领导层非常有能力和热情，并且坚定地致力于EDRN的目标。此外，UCLA- brl得到了来自医学院、Jonsson综合癌症中心、UCLA肺癌孢子和UCLA前列腺癌孢子的强有力的机构支持。