Arrival of the fittest: examining the underlying mechanisms of morphological plasticity in an adaptive radiation
适者生存:检查适应性辐射中形态可塑性的潜在机制
基本信息
- 批准号:2749591
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2021
- 资助国家:英国
- 起止时间:2021 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Studentship strategic priority area: BiodiversityKeywords: Evolution, plasticity, gene expression, boneAbstract: Phenotypic plasticity currently drives contentious debate in evolutionary biology. This debate deals with the role of environmental cues in generating biodiversity, species, and ultimately the utility of the standard Darwinian synthesis (or its extension). While plasticity is a topic of much empirical research with growing relevance to environmental change, we still lack a general understanding of the underlying mechanisms of plasticity in evolutionary systems. This studentship will draw on knowledge from bone biology to fill this gap, specifically focusing on how bones interpret the mechanosensory stimuli that instruct their growth and produce adaptive variation. A central dogma in bone biology is that osteocytes (mechanosensory cells) are the sole mechanism for bone to respond to mechanical stress. However, not all animals with bones possess osteocytes (most fishes having lost them), and there are emerging alternatives which our preliminary data point toward. Specifically, our previous research has identified variation in the magnitude of bone plasticity between related species of African cichlids. Cichlids are an exemplary system for evolutionary biologists in that they are derived from a recent common ancestor but exhibit vast amounts of adaptive skeletal variation. This variation appears to be controlled by a few mutations on a common genetic background. So far we have combined plasticity experiments with QTL mapping approaches to identify a number of candidate 'plasticity genes' in the craniofacial skeleton. These genes include members of signalling pathways previously implicated in bone development (Wnts, BMPs, FGFs), and structural genes including rootletin - a key component of the primary cilia and representative of a potential alternative mechanism for mechanosensory function. These findings provide a strong basis for understanding the molecular and cellular mechanisms involved in plasticity and their contribution to evolution.
学生奖学金战略优先领域:生物多样性关键词:进化,可塑性,基因表达,骨摘要:表型可塑性目前驱动器在进化生物学有争议的辩论。这场辩论涉及环境线索在产生生物多样性、物种以及最终标准达尔文综合(或其扩展)的效用中的作用。虽然可塑性是许多实证研究的主题,与环境变化的相关性越来越大,但我们仍然缺乏对进化系统中可塑性的基本机制的普遍理解。该研究将利用骨骼生物学的知识来填补这一空白,特别关注骨骼如何解释指导其生长并产生适应性变化的机械感觉刺激。骨生物学的中心法则是骨细胞(机械感觉细胞)是骨对机械应力做出反应的唯一机制。然而,并不是所有有骨的动物都拥有骨细胞(大多数鱼类都失去了它们),我们的初步数据指出了正在出现的替代品。具体来说,我们以前的研究已经确定了非洲慈鲷科相关物种之间的骨可塑性大小的变化。慈鲷是进化生物学家的一个典型系统,因为它们来自最近的共同祖先,但表现出大量的适应性骨骼变异。这种变异似乎是由一个共同的遗传背景上的一些突变控制的。到目前为止,我们已经结合可塑性实验与QTL定位方法,以确定一些候选的“可塑性基因”的颅面骨骼。这些基因包括先前与骨发育有关的信号传导途径的成员(Wnt、BMP、FGF),以及包括rootaoke(初级纤毛的关键组分,代表机械感觉功能的潜在替代机制)在内的结构基因。这些发现为理解可塑性的分子和细胞机制及其对进化的贡献提供了强有力的基础。
项目成果
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其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
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LiDAR Implementations for Autonomous Vehicle Applications
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2021 - 期刊:
- 影响因子:0
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吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
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Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
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