Genetics of coordinately evolving patterns and behavior

协调进化模式和行为的遗传学

• 批准号: 7015333
• 负责人: JOHN R TRUE
• 金额: $ 25.2万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7015333
• 关键词: Drosophilidae; arthropod genetics; behavioral /social science research tag; behavioral genetics; biochemical evolution; ethology; genetic polymorphism; linkage mapping; male; phenotype; pigmentation; polymerase chain reaction; quantitative trait loci; species difference

DESCRIPTION (provided by applicant): The genetic architecture underlying natural variation in complex trait assemblages is not well understood. Elucidating this architecture could contribute greatly to our knowledge of the mechanisms promoting developmental and behavioral diversity and novelty, as well as provide models for understanding genetically based variation in complex human traits. The proposed project aims to develop linkage and QTL maps in the Drosophila elegans/gunungcola species pair to determine the molecular genetic basis of intra- and interspecies variation in body color and interspecies divergence in two male-specific traits, wing spots and wing courtship display, that are tightly evolutionarily associated. Specifically, this work is designed to address three longstanding questions on the origins and dynamics of morphogenetic and behavioral diversity. First, deciphering the genetics of pigmentation and behavioral divergence in these species will provide important insights on the types of loci and alleles underlying the responses of morphogenetic and behavioral pathways to natural and sexual selection. Second, mapping the positions of quantitative trait loci (QTLs) for each trait will help to reveal whether the genetic architectures of evolutionarily associated traits are independent or connected by linkage or pleiotropy. Third, comparing the genetic basis of body color variation within and between species will indicate whether the mechanisms underlying between-species divergence are similar to or distinct from those underlying within-species polymorphism, thus testing a main tenet of the neo-Darwinian evolutionary synthesis. These questions are also of great interest to developmental and behavioral biologists, who seek to determine the molecular genetic basis of complex, species-specific phenotypes and whether genetic information from model species can be applied across taxa. Because evolutionary change in male wing pigment patterns and display behaviors has occurred repeatedly in the Oriental melanogaster group lineages, our results will also enable us to investigate whether independent cases of pigmentation and courtship evolution involve similar or distinct genetic underpinnings.

描述（由申请人提供）：复杂性状组合中自然变化的遗传结构尚不清楚。阐明这种体系结构可能会极大地有助于我们对促进发展和行为多样性和新颖性的机制的了解，并为理解复杂人类特征的基于遗传的变异提供了模型。拟议的项目旨在在果蝇秀丽隐杆线虫/甘格洛拉物种对中开发连锁和QTL图，以确定身体颜色内部和种间种间变化的分子遗传基础，在两个男性特异性特征性状，翼圈和翼姿势展示中，有密切相关的侧面特异性特征性状和杂物差异。具体而言，这项工作旨在解决有关形态发生和行为多样性的起源和动态的三个长期问题。首先，对这些物种的色素沉着和行为差异的遗传学解密将提供有关基因座和等位基因类型的重要见解，该基因座和等位基因对形态发生和行为途径对自然和性选择的反应。其次，映射每个性状的定量性状基因座（QTL）的位置将有助于揭示进化相关性状的遗传结构是通过链接或多效性而独立或连接的。第三，将物种内部和物种之间的身体颜色变异的遗传基础进行比较，将表明种族之间差异之间的机制是否类似于或与潜在物种内部多态性的机制相似或与众不同，从而测试了新戴维尼人进化合成的主要原则。这些问题也引起了发育和行为生物学家的极大兴趣，他们试图确定复杂的，物种特异性表型的分子遗传基础，以及是否可以在模型物种中应用来自模型物种的遗传信息。由于在东方Melanogaster组谱系中反复发生了男性机翼色素模式和表现行为的进化变化，因此我们的结果还将使我们能够研究独立的色素沉着和求爱进化案例是否涉及类似或独特的遗传基础。