Smoking and Metabolic Complications in Adolescent Girls

青春期女孩的吸烟和代谢并发症

• 批准号: 7019147
• 负责人: LORAH Denise DORN
• 金额: $ 66.49万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7019147
• 关键词: adolescence (12-20); adrenal glands; anxiety disorders; behavioral /social science research tag; blood chemistry; body composition; body physical activity; bone metabolism; clinical research; depression; dietary calcium; female; gonads; health behavior; human puberty; human subject; longitudinal human study; menstrual cycle; normal ossification; photon absorptiometry; psychological tests; smoking; statistics /biometry

DESCRIPTION (provided by applicant): Adolescence is a time of vulnerability for youth where depression rates increase, particularly in girls, and smoking behaviors are also initiated. Increased morbidity and mortality in women who are smokers has been highlighted by recent statistics showing that women now have an increased rate of smoking over the last several decades. Morbidity and mortality is usually defined by cardiovascular and respiratory disorders. Less attention has been paid to the effect of smoking on aspects of health such as the relationship between smoking and depression and anxiety, and in turn, their combined effects on reproductive and bone health. No studies have examined such issues in puberty. The aims of this study are to examine: (1) baseline relationships between puberty, smoking status, depression anxiety, reproductive and bone health, (2) causal direction between smoking status and depression and anxiety across 3 years, (3) characteristics of individual differences in developmental trajectories of: (a) reproductive and (b) bone health (accrual of bone mineral content; BMC) across a 3 year period, (4) the systematic effects of timing of puberty, smoking status and depression and anxiety on individual differences in developmental trajectories of reproductive and bone health (accrual of BMC) across a 3 year period, (5) the relationship of individual differences in developmental trajectories of adolescent reproductive health with individual differences in developmental trajectories of bone health across a 3 year period, and (6) whether baseline levels of smoking status, depression, and pubertal timing predict the simultaneous developmental trajectories of reproductive and bone health. The study will include 252 girls, ages 11-17 years enrolled in a cross-sequential design for three annual visits. Measures include smoking status, depression and anxiety, pubertal timing, gonadal and adrenal hormones, menstrual cycle information, and accrual of BMC. Examining the combined impact of smoking, depression and anxiety, on timing of puberty has import for future intervention and prevention strategies. Any negative influence during this critical period, such as smoking or depression, may have significant long-term consequences for bone (i.e. increased risk of osteoporotic fracture) or reproductive health (i.e. menstrual irregularity & endocrine disruption, infertility, dysmenorrhea).

描述（由申请人提供）：青春期是抑郁症率增加的年轻人的脆弱时代，尤其是女孩，也开始吸烟行为。最近的统计数据表明，在过去的几十年中，妇女现在的吸烟率提高了，吸烟者的发病率和死亡率提高了。发病率和死亡率通常由心血管和呼吸系统疾病定义。人们对吸烟对健康方面的影响（例如吸烟与抑郁和焦虑之间的关系）的关注较少，进而对它们对生殖和骨骼健康的综合影响。没有研究在青春期检查了此类问题。这项研究的目的是研究：（1）青春期，吸烟状况，抑郁症焦虑，生殖和骨骼健康之间的基线关系，（2）3年吸烟状况与抑郁症与焦虑之间的因果方向，（（3），（3）发育轨迹的个性特征：（a）生殖和（b）骨骼健康（b）骨骼矿物质的骨骼矿物质的影响； B骨矿物质的影响；在3年期间，青春期，吸烟状况以及抑郁症以及对生殖和骨骼健康发展轨迹的个体差异（BMC的应计）的焦虑，（5）（5）（5）在青少年生殖健康发展轨迹中个体差异的关系，个人差异与个体在3年的骨骼健康状况中的骨骼健康范围以及（6）的次数降低（6）的骨骼健康状况以及（6）的状态，以及（6）的状态，以及（6）的状态，以及（6）的状态（6）生殖和骨骼健康的轨迹。这项研究将包括252名11-17岁的女孩，他们参加了三场年度访问的盘顺序设计。措施包括吸烟状况，抑郁和焦虑，青春期的时机，性腺和肾上腺激素，月经周期信息以及BMC的应计。检查吸烟，抑郁和焦虑对青春期时机的综合影响，可以进口未来的干预和预防策略。在这个关键时期的任何负面影响，例如吸烟或抑郁症，可能会对骨骼（即增加骨质疏松性骨折的风险增加）或生殖健康（即月经不规则性和内分泌不育症，不育，肌酸）产生重大的长期影响。