Core--Pulmonary Toxicology

核心--肺毒理学

• 批准号: 6867267
• 负责人: GUNTER OBERDORSTER
• 金额: $ 5.96万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6867267
• 关键词: air pollution; biomedical facility; environmental contamination; environmental exposure; environmental health; environmental toxicology; inflammation; oxidative stress; pulmonary respiration; respiratory disorder; respiratory toxin

Description (provided by applicant): The overall aim of this core is to evaluate mechanisms of oxidative injury, inflammation and repair in both the respiratory and cardiovascular systems caused by environmental and occupational agents. This aim has been a central focus for the core since the 1940?s when Rochester first began investigation into the pulmonary toxicology of airborne particulates. Focus today continues not only on airborne particulates, but also on oxidant gases, endotoxin, siloxanes, zinc oxide and ionizing radiation. Experimental approaches range from basic cellular and molecular methods to animal and clinical human studies. The core studies the impact of inhaled agents in asthma, COPD, fibrosis and lung cancer. Factors that modulate the toxicological effects of inhaled agents, such as age and underlying disease, are also studied. A new approach that has evolved over the last 5 years is the focus on systemic effects of inhaled agents, in particular effects on the cardiovascular system. Nearly 50% of the 181 publications cited since the last renewal are joint authored by members of the core, speaking to the intense collaborative effort underway. The studies carried out by core members result in publications in strong, high-impact scientific journals (AJP Lung, AJRCCM, Environ Health Perspectives, J Immunol, Inhalation Toxicol). All members are now housed under one roof with the construction of a new research building, enhancing the collaborative effort.

描述（由申请人提供）：该核心的总体目标是评价由环境和职业因素引起的呼吸系统和心血管系统的氧化损伤、炎症和修复机制。自1940年以来，这一目标一直是核心的中心焦点。这是罗切斯特第一次开始研究空气中颗粒物的肺毒理学。今天的重点不仅继续放在空气中的颗粒物上，而且还放在氧化剂气体、内毒素、硅氧烷、氧化锌和电离辐射上。实验方法从基本的细胞和分子方法到动物和临床人类研究。核心研究吸入剂对哮喘、慢性阻塞性肺病、纤维化和肺癌的影响。调节吸入剂的毒理学效应的因素，如年龄和基础疾病，也进行了研究。在过去5年中发展的一种新方法是关注吸入剂的全身效应，特别是对心血管系统的影响。自上次更新以来，引用的181篇出版物中有近50%是由核心成员共同撰写的，这说明了正在进行的密切合作。核心成员开展的研究成果在强大的高影响力科学期刊上发表（AJP Lung，AJRCCM，Environ Health Perspectives，J Immunol，Inhalation Toxicol）。所有成员现在都住在一个屋顶下，建造了一座新的研究大楼，加强了合作努力。