Development of a Wearable Seizure Warning Device

开发可穿戴式癫痫警告装置

• 批准号: 7155466
• 负责人: GEORGIY R MINASYAN
• 金额: $ 10.69万
• 依托单位: CHATTEN ASSOCIATES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7155466
• 关键词: children; consciousness; epilepsy; injury; performance; public health; thinking

DESCRIPTION (provided by applicant): In spite of advances in medical and surgical treatment, there are at any one time estimated to be some 350,000 individuals in this country whose seizures occur without warning and result in some combination of disordered thinking, impaired consciousness, or loss of motor control. Epileptologists and patients alike have long understood the magnitude of this problem and wished for a means of seizure warning that would allow self-protection or, in some cases, protective action on the part of caretaker. In spite of high perceived need and advances analytic and electronic technology, no seizure warning device exists that could be worn and used widely in situations that might range from children in a caretaker setting to independent adults in the workplace. We will design, test and manufacture a Wearable Seizure Warning Device (WSWD) by combining our experience in seizure warning (using scalp electrodes and some use of EKG) with state-of-the-art handheld wireless computer hardware/software and a digital EEG amplifier/transmitter of our own design. In Phase I, we propose to (1) optimize our seizure warning software parameters and algorithms for use in a WSWD environment, (2) port the seizure warning software to a handheld computer platform and evaluate its performance on prerecorded data, and (3) select an approach and perform an initial design for the amplifier hardware and interfaces. During Phase II the prototype hardware will be developed and clinically tested and the FDA approval phase initiated. Even with major advances in medical and surgical treatment for epilepsy, recurrent epileptic seizures remain a significant public health problem in the United States and around the world. When seizures occur in a critical setting, the person with epilepsy and those around him/her may be exposed to a high risk of injury, error, and embarrassment. During this project, over Phases I and II, we expect to develop a wearable seizure warning device that will be useful and acceptable to a significant portion of those patients whose seizures are not adequately controlled.

描述（由申请人提供）：尽管医疗和手术治疗方面取得了进步，但据估计，在这个国家，有大约350,000名个人在没有警告的情况下发生癫痫发作，并导致某种混乱的思维，意识受损或失去运动控制。癫痫病医生和患者长期以来一直了解此问题的幅度，并希望采取癫痫发作的警告手段，该警告将允许自我保护，或者在某些情况下是对看守者的保护作用。尽管有高度的需求和进步分析和电子技术，但尚无癫痫发作警告装置，可以在看护人环境中的儿童到工作场所中的独立成年人，可以佩戴并广泛使用。我们将通过将我们在癫痫发作警告（使用头皮电极和某些使用EKG的使用）与最先进的手持无线计算机硬件/软件以及数字EEG EEG放大器/发射器相结合，设计，测试和制造可穿戴的癫痫发警告设备（WSWD）。在第一阶段，我们建议（1）优化我们的癫痫发作警告软件参数和算法以在WSWD环境中使用，（2）将癫痫发作警告软件移到手持计算机平台上，并在预先记录的数据上评估其性能，以及（3）选择一种方法，并为放大器硬件和Interface和Intir tess设计。在第二阶段期间，原型硬件将进行开发和临床测试，并启动FDA批准阶段。即使在癫痫的医学和外科手术治疗方面取得了重大进展，在美国和世界各地，复发性癫痫发作仍然是一个重大的公共卫生问题。当癫痫发作在关键环境中发生时，患有癫痫的人，周围的人可能会面临高伤害，错误和尴尬的高风险。在此项目中，在第I和II阶段，我们希望开发一种可穿戴的癫痫发警告装置，该警告设备对于那些癫痫发作的患者中的很大一部分将是有用的，并且可以接受。