Peripheral Nerve Stimulation for Bladder Emptying

周围神经刺激促进膀胱排空

• 批准号: 7108237
• 负责人: Joseph Wilder Boggs
• 金额: $ 12.66万
• 依托单位: NDI MEDICAL, LLC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7108237
• 关键词: afferent nerve; clinical research; electrodes; lead

DESCRIPTION (provided by applicant): Over 200,000 Americans with spinal cord injury (SCI), who cannot voluntarily control their lower urinary tract, have health problems and a decreased quality of life. Presently, one product using electrical stimulation applied to the sacral nerve roots to restore bladder emptying (VOCARE, Finetech Medical, UK) is commercially available, but it is not widely accepted among the potential patient population because it involves an invasive surgical procedure and requires permanently severing afferent nerves. The long-term goal of this project is to develop and commercialize a less invasive alternative neurostimulation product that does not require nerve transection. The specific aim of this Phase I proposal is to demonstrate the feasibility of eliciting bladder contractions to expel stored urine by electrical stimulation of urethral afferent pathways in the pudendal nerve (PN) in persons with SCI. The hypothesis is that PN afferent stimulation will activate a spinal reflex enabling bladder emptying with low residual volumes without requiring the transection of afferent nerves. This hypothesis will be tested in humans with SCI by stimulating PN afferents with a minimally invasive catheter-electrode technique and measuring 1) bladder pressure evoked by stimulation and 2) bladder volume before and after stimulation. At the conclusion of this Phase I project, we will have determined the feasibility of emptying the bladder by electrical stimulation of the PN afferents in persons with SCI.

描述（由申请人提供）：超过 200,000 名患有脊髓损伤 (SCI) 的美国人无法自主控制下尿路，存在健康问题和生活质量下降。目前，一种使用电刺激骶神经根以恢复膀胱排空的产品（VOCARE，Finetech Medical，英国）已上市，但它并未在潜在患者群体中广泛接受，因为它涉及侵入性外科手术，并且需要永久切断传入神经。该项目的长期目标是开发一种不需要神经横断的侵入性较小的替代神经刺激产品并将其商业化。该第一阶段提案的具体目的是证明通过电刺激 SCI 患者阴部神经 (PN) 的尿道传入通路引起膀胱收缩以排出储存的尿液的可行性。假设 PN 传入刺激将激活脊髓反射，使膀胱排空且残余容量低，而不需要横断传入神经。这一假设将在患有 SCI 的人类身上进行测试，方法是使用微创导管电极技术刺激 PN 传入神经，并测量 1) 刺激引起的膀胱压力和 2) 刺激前后的膀胱体积。在第一阶段项目结束时，我们将确定通过电刺激 PN 传入神经对 SCI 患者排空膀胱的可行性。

项目成果

Electrical stimulation of the urethra evokes bladder contractions in a woman with spinal cord injury.

电刺激尿道会引起脊髓损伤女性的膀胱收缩。

• DOI: 10.1080/10790268.2010.11689704
• 发表时间: 2010
• 期刊: The journal of spinal cord medicine
• 作者: Kennelly,MichaelJ;Arena,KimberlyC;Shaffer,Nell;Bennett,MariaE;Grill,WarrenM;Grill,JulieH;Boggs,JosephW
• 通讯作者: Boggs,JosephW