Resolving the impact of low-fibre therapeutic diets on the human microbiome through integrated 'omics

通过综合“组学”解决低纤维治疗饮食对人类微生物组的影响

• 批准号: 2750801
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2750801
• 关键词: Resolving; impact; low; fibre; therapeutic

The microbiome is one of the most exciting current areas of medical research with significant implications for human health and disease. We have partnered with Eagle Genomics [https://www.eaglegenomics.com/] to conduct a project that aims - through a combination of in vitro experiments and bioinformatics analysis of high dimensional sequence and metabolome data sets - to determine the precise role of the gut microbiome in Crohn's disease, an important, often incapacitating, inflammatory disease of the gut. The exact aetiology of Crohn's disease is not yet understood but the microbiome is strongly implicated almost certainly through an interaction with the immune system. Dietary therapy is one of the most effective treatments for CD with the advantage of reduced side effects compared to drugs such as steroids. It also provides the opportunity, through studying changes as individual patients get better, to fully understand the causes of Crohn's. In addition, if we can understand the mechanism for the treatment action of the diets, then we can improve remission rates through microbiome modulation prior to or after treatment.

微生物组是当前医学研究中最令人兴奋的领域之一，对人类健康和疾病具有重大影响。我们与鹰基因组[https://www.eaglegenomics.com/]]合作开展了一个项目，旨在通过体外实验和对高维序列和代谢组数据集的生物信息学分析，确定肠道微生物群在克罗恩病中的确切作用，克罗恩病是一种重要的、通常使人丧失能力的炎症性疾病。克罗恩病的确切病因尚不清楚，但微生物组几乎肯定通过与免疫系统的相互作用而被强烈牵连。饮食疗法是治疗CD最有效的治疗方法之一，与类固醇等药物相比，其副作用较少。它还提供了机会，通过研究随着个别患者病情好转而发生的变化，充分了解克罗恩病的原因。此外，如果我们能够了解饮食治疗作用的机制，那么我们可以在治疗前后通过微生物群调节来提高缓解率。