EFFECT OF SYSTEMIC LUPUS ERYTHMATOSUS IN MINORITIES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目的目的是研究人口统计学、社会经济和遗传因素在决定系统性红斑狼疮（SLE）患者病程和早期结局中的相互关系。该研究在德克萨斯州的休斯顿和加尔维斯顿以及波多黎各设有中心，除了跟踪非裔美国人和白种人SLE患者外，还跟踪了两个不同地点的西班牙裔患者：德克萨斯州和波多黎各。LUMINA研究的另一个维度是PROFILE子研究。PROFILE是UAB SLE遗传学PO1项目的第4个项目。其目的是确定遗传学在狼疮结果中所起的作用。因此，不仅获得了患者DNA来研究SLE相关基因，而且还招募了父母和兄弟姐妹（TRIO家族），以便对他们的DNA进行分析。迄今为止的研究结果表明，西班牙裔和非裔美国患者的SLE活动性更强，发病年龄更早，社会经济人口结构较差（西班牙裔比非裔美国人更差），这使他们的自然病史较差。(害怕Alarc n, 1999年)

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this project is to study the inter-relationship between demographic, socioeconomic, and genetic factors in determining the course and early outcome in patients with systemic lupus erythematosus (SLE). This study has centers in Houston and Galveston, Texas as well in Puerto Rico, which in addition to following African-American and Caucasian patients with SLE, follows Hispanic patients at 2 different locations: Texas and Puerto Rico. An added dimension of the LUMINA study is the PROFILE sub-study. PROFILE is Project 4 of the PO1 Program Project in the genetics of SLE at UAB. Its goal is to determine the role that genetics plays in the outcome of lupus. As such, not only is patient DNA obtained to investigate genes related to SLE, but parents and siblings are being recruited (TRIO families) so that their DNA may be analyzed as well. Results to date indicate that Hispanic and African-American patients have more active SLE, at an earlier age of onset, and a less favorable socioeconomic-demographic structure (worse among Hispanics than African-American), which predispose them to a less favorable natural history. [Alarc¿n, 1999]