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OUTCOME OF SYSTEMIC LUPUS ERYTHEMATOSUS IN MINORITIES--NATURE VS NURTURE

OUTCOME OF SYSTEMIC LUPUS ERYTHEMATOSUS IN MINORITIES--NATURE VS NURTURE
少数族裔系统性红斑狼疮的结果——先天与后天
批准号：
6303042
负责人：
Graciela S Alarcon
金额：
$2.95万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6303042
关键词：
African American Hispanic Americans MHC class II antigen autoantibody caucasian American clinical research culture epidemiology genotype human morbidity human population study human subject longitudinal human study outcomes research pathologic process racial /ethnic difference socioeconomics systemic lupus erythematosus

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中文摘要
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英文摘要
The purpose of this project is to study the inter-relationship between demographic, socioeconomic, and genetic factors in determining the course and early outcome in patients with systemic lupus erythematosus (SLE). This study has centers in Houston and Galveston, Texas, as well which, in addition to following African-American and Caucasian patients with SLE, follows Hispanic patients as well. An added dimension of the LUMINA study is the PROFILE sub-study. PROFILE is Project 4 of the Specialized Center of Research in SLE at UAB. Its' goal is to determine the role that genetics play in the outcome of lupus. As such, not only is patient DNA obtained to investigate genes related to SLE, but parents and siblings are being recruited (TRIO families) so that their DNA may be analyzed as well.
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