USF Scholars in Patient-Oriented Research (SPOR)

描述(由申请人提供)： 这是一项针对南佛罗里达大学(USF)以患者为中心的学者研究(SPOR)计划的提案。过去10年，USF朝着成为一所主要研究型大学的目标迈进了一大步，将外部研究资金从每年不到2500万美元增加到近2.5亿美元。超过一半的资金来自健康科学中心(HSC)。目前，这些资金中约有一半来自行业赞助的临床治疗试验，另一半资金用于研究人员发起的研究。因此，USF HSC的优先事项是集中培养一支强大的教职员工队伍，他们在以患者为导向的研究方面具有专业知识，能够接受同行审查的外部资助。此外，我们显然需要升级专科研究员培训计划，以培训越来越多的专科研究员成为学术、临床和翻译研究人员。K30赠款是启动这些努力的理想机制。幸运的是，在我们机构内，莫菲特癌症中心，一个由NCI指定的综合癌症中心，在建立临床研究计划、为初级教师提供临床和翻译研究指导计划以及NCI K12资助的临床和翻译研究培训计划方面做了出色的工作。拟议的计划将利用莫菲特开发的专业知识，以及USF的许多较小的临床研究专业知识，来培训初级教员和研究员。Spor项目将使你获得硕士学位。它将包括一个核心的课堂和基于网络的教学，以及一个有指导的临床研究项目。许多课程已经存在，其他课程将从现有课程衍生而来，而一些课程将专门为Spor计划学员设计。必修课将包括：研究和职业道德；专家精神；科学写作；临床研究的多样性；细胞生物学、生理学、药理学和分子生物学的原理；生物统计学和信息学；成功的以病人为中心的研究的基础。将提供三个方面：治疗性临床研究人员(临床试验设计；第一/第二阶段临床试验设计、进行、分析和资助)；基于人群的研究(流行病学和试验设计)；人类疾病机制(新陈代谢的分子基础、临床药理学、生物信息学)。将需要一篇基于指导研究的论文或同行评议的出版物(S)。执行委员会将监督该计划，并将设立小组委员会，负责(1)学员选择，(2)导师选择(3)课程(4)评估过程，以及(5)SPOR计划的整体进展。过程评估将基于对课程、指导性研究和整个计划的评估。评估的主要长期结果将包括学术职位受训人员的数量，从事生产性临床研究(手稿和摘要)的受训人员，以及具有国家同行审查资助的临床和翻译研究项目的受训人员的数量。

DESCRIPTION (provided by applicant): This is a proposal is for a Scholars in Patient-Oriented Research (SPOR) Program at the University of South Florida (USF). USF has made major strides over the past decade toward the goal of becoming a major research university increasing external research funding from less than $25M to nearly $250M annually. Over half of this funding is in the Health Sciences Center (HSC). About half of this funding currently is from industry-sponsored clinical therapeutic trials, and with the other half of the funding is for investigator-initiated research. Thus, it is a priority of the USF HSC to concentrate on developing a strong cadre of faculty members with expertise in patient-oriented research that is capable of receiving peer-reviewed external funding, in addition, we have a clear need to upgrade the subspecialty fellowship training programs to train increasing numbers of subspecialty fellows to become academic clinical and translational researchers. The K30 grant is an ideal mechanism for jumpstarting these efforts. Fortunately, within our institution the Moffitt Cancer Center, an NCI-designated Comprehensive Cancer Center, has done an outstanding job of building a clinical research program, a clinical and translational research mentoring program for junior faculty, and a NCI K12- funded Clinical and Translational Research Training program. The proposed program will utilize the expertise developed at Moffitt, as well as many of the smaller foci of clinical research expertise at USF, to train junior faculty and fellows. The SPOR Program will lead to a Masters degree. It will consist of a core of classroom and web-based didactic teaching and a mentored clinical research project. Many of the courses already exist, and others will be derived from current courses, whereas some courses will be designed specifically for SPOR Program trainees. Required courses will include research and professional ethics; grantsmanship; scientific writing; diversity in clinical research; principles of cell biology, physiology, pharmacology, and molecular biology; biostatistics and informatics; fundamentals of successful patient-oriented research. There will be three tracks available: therapeutic clinical researchers (clinical trial design; Phase I/II clinical trial design, conduct, analysis and funding), population-based research (epidemiology and trial design), mechanisms of human disease (molecular basis of metabolism, clinical pharmacology, bioinformatics). A thesis or peer-reviewed publication(s) based on mentored research will be required. The executive committee will oversee the Program and will have subcommittees for (1) trainee selection, (2) mentor selection (3) curriculum (4) evaluation processes; and (5) overall SPOR Program progress. Process assessment will be based on evaluations of courses, mentored research, and the Program overall. The major long-term outcomes evaluated will include the number of trainees in academic positions, trainees doing productive clinical research (manuscripts and abstracts), and trainees with national peer-review funded clinical and translational research proqrams.