Spatiotemporal ERP Modeling & Brain Development

时空 ERP 建模

• 批准号: 7111156
• 负责人: JOSEPH R ISLER
• 金额: $ 17.1万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7111156
• 关键词: baboons; brain; clinical research; computational biology; computational neuroscience; computer data analysis; computer simulation; developmental neurobiology; electroencephalography; embryo /fetus; evoked potentials; human subject; infant animal; mature animal; method development; neurogenesis; postdoctoral investigator; training

DESCRIPTION (provided by applicant): The candidate for the award is a PhD atmospheric physicist seeking to redirect his career into quantitative research in neuroscience. He was a highly productive NSF funded investigator in atmospheric dynamics. With his strong background in physics, nonlinear dynamics, time series analysis, applied mathematics and computer simulations of complex systems he has already made remarkable strides in pursuit of this new career. During his post-doctoral fellowship in developmental psychobiology, he has demonstrated a strong potential to be a significant member of a multi-disciplinary team and a definite commitment to quantitative neuro-developmental research, witnessed by his contributions to the literature and extensive initial results. The scientific objective of the award is to develop new quantitative methods of analysis for event related potential (ERP) experiments performed in adults, infants and fetal primates, and then to link these experimental results to computational neural models that will simulate development of the underlying neural systems. Specific hypotheses regarding source networks of the MMN (mismatch negativity) and P3a "oddball" ERP components will be tested with the new methods. Results should lead to the development of new clinical and diagnostic tools that assess the integrity of cortical function in infants and non-responsive adults. His career award plan has been carefully structured to substantially contribute to his scientific development. His has unique needs that will be met with specific clinical and didactic resources and formal course work including a seminar in responsible conduct of research. He will be conscientiously mentored with guidance and advice from a team of individuals chosen for their interests in collaboration and availability, appropriateness of expertise and resources, and previous success in fostering the progress of researchers.

描述（由申请人提供）：该奖项的候选人是一位博士大气物理学家，寻求将他的职业生涯重新定向到神经科学的定量研究。他是一个非常富有成效的国家科学基金会资助的研究员在大气动力学。凭借他在物理学，非线性动力学，时间序列分析，应用数学和计算机模拟复杂系统的强大背景，他已经取得了显着的进步，在追求这个新的职业生涯。在他的发展心理生物学博士后研究期间，他表现出了成为多学科团队重要成员的强大潜力，并明确致力于定量神经发育研究，他对文献的贡献和广泛的初步成果证明了这一点。该奖项的科学目标是为在成人，婴儿和胎儿灵长类动物中进行的事件相关电位（ERP）实验开发新的定量分析方法，然后将这些实验结果与模拟潜在神经系统发育的计算神经模型联系起来。具体的假设源网络的MMN（不匹配负性）和P3a的“古怪”ERP组件将与新的方法进行测试。结果将导致新的临床和诊断工具的开发，以评估婴儿和无反应的成人皮质功能的完整性。他的职业奖励计划经过精心设计，为他的科学发展做出了重大贡献。他有独特的需求，将满足具体的临床和教学资源和正式的课程工作，包括在负责任的研究行为的研讨会。他将认真指导指导和建议，从一个团队的个人选择他们的利益在合作和可用性，专业知识和资源的适当性，以及以前的成功，促进研究人员的进步。