Late-life Depression Outcomes in the Medically Ill

患有疾病的人晚年抑郁症的结果

• 批准号: 7025787
• 负责人: JEFFREY M LYNESS
• 金额: $ 13.18万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7025787
• 关键词: clinical research; disease /disorder proneness /risk; functional ability; health care service utilization; human mortality; human old age (65+); human subject; major depression; outcomes research; patient oriented research; religion

DESCRIPTION (provided by applicant): This application for an NIMH Mid-Career Investigator Award in Patient-Oriented Research (K24) requests support for the Pi's continued career development and emergence as a leader nationally, as a clinical researcher and as a mentor to more junior investigators. The investigative focus is the relationships of depression and medical comorbidity in older adults, including their associations with key quality of life outcomes during the latter stages of life. Integrated research and mentoring plans are proposed with the following goals: (1) To continue to develop the Pi's research program on depression and medical comorbidity in primary care elders, specifically examining the naturalistic history of minor and subsyndromal depressive conditions, and to extend his previous work by testing psychological moderators and studying end of life outcomes. This will be supported by a current R01 (Project 1) and by a planned competitive continuation R01 application (Project 2). (2) To further extend the Pi's research by examining the relationships among depression and specified biological and psychological factors, and their associations with quality of life outcomes and mortality, in older patients with severe heart failure. This new initiative's pilot phase will be followed by an R01-supported study (Project 3). Heart failure is the leading cause of death among older adults, complementing Project 2's 'latter stages of life' theme. (3) To train junior investigators from a range of clinical backgrounds, including physicians, in the design and conduct of geriatric psychiatry studies, particularly those related to depression and medical comorbidity. The application describes the mentoring plans and their feasibility, including the Pi's qualifications, plans for further development of his mentoring skills, and the resources to attract and support trainees. Projects 1-3, and other funded investigations, will be the main research vehicles for such training. Trainees at the Pi's institution will be supported by several existing or pending institutional training grants. The PI also will mentor early career researchers at other institutions through national-level training grants and meetings.

描述(由申请人提供)：这份申请NIMH以患者为中心的研究(K24)职业中期研究员奖的申请请求支持PI的持续职业发展和作为全国领导者、临床研究人员和更初级研究人员的导师。研究的重点是老年人抑郁和医学共病的关系，包括它们与生命后期关键生活质量结果的关系。提出了综合研究和指导计划，目标如下： (1)继续发展PI关于初级保健老年人抑郁和医学共病的研究计划，特别是考察轻微和亚综合征抑郁状况的自然历史，并通过测试心理调节因子和研究临终结果来扩展他以前的工作。这将得到当前R01(项目1)和计划中的竞争延续R01申请(项目2)的支持。(2)通过研究抑郁与特定的生物和心理因素之间的关系，以及它们与老年严重心力衰竭患者的生活质量和死亡率的关系，进一步扩展PI的研究范围。在这一新倡议的试验阶段之后，将进行由R01支持的研究(项目3)。心力衰竭是导致老年人死亡的主要原因，这是对项目2《S晚年》主题的补充。(3)培训来自不同临床背景的初级研究人员，包括医生，以设计和进行老年精神病学研究，特别是与抑郁症和医学合并症有关的研究。申请书描述了辅导计划及其可行性，包括PI的资历、进一步发展其辅导技能的计划，以及吸引和支持受训人员的资源。项目1-3以及其他由资金资助的调查将是此类培训的主要研究工具。该机构的受训人员将得到若干现有或待批的机构培训补助金的支持。PI还将通过国家一级的培训赠款和会议指导其他机构的早期职业研究人员。