Late-life Depression Outcomes in the Medically Ill

患有疾病的人晚年抑郁症的结果

• 批准号: 7195008
• 负责人: JEFFREY M LYNESS
• 金额: $ 13.56万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7195008
• 关键词: Attention; Award; Biological; Categories; Cause of Death; Clinical; Comorbidity; Complement; Condition; Depressed mood; Development; Diagnosis; Diagnostic; Dysthymic Disorder; Educational Status; Elderly; Event; Factor Analysis; Funding; Geriatric Psychiatry; Goals; Grant; Heart failure; Institution; Intake; Investigation; Life; Major Depressive Disorder; Mediating; Medical; Mental Depression; Mentors; Minor; Modeling; National Institute of Mental Health; Neurotic Disorders; Outcome; Pathogenesis; Patients; Personality Traits; Phase; Physicians; Primary Health Care; Psychological Factors; Psychological Tests; Quality of life; Range; Recording of previous events; Research; Research Personnel; Resources; Risk Factors; Severities; Social support; Specific qualifier value; Staging; Testing; Training; Work; burden of illness; career; cerebrovascular; cost; depressive symptoms; design; end of life; follow-up; functional disability; functional status; geriatric depression; health care service utilization; minor depressive disorder; mortality; older patient; patient oriented research; programs; skills

DESCRIPTION (provided by applicant): This application for an NIMH Mid-Career Investigator Award in Patient-Oriented Research (K24) requests support for the Pi's continued career development and emergence as a leader nationally, as a clinical researcher and as a mentor to more junior investigators. The investigative focus is the relationships of depression and medical comorbidity in older adults, including their associations with key quality of life outcomes during the latter stages of life. Integrated research and mentoring plans are proposed with the following goals: (1) To continue to develop the Pi's research program on depression and medical comorbidity in primary care elders, specifically examining the naturalistic history of minor and subsyndromal depressive conditions, and to extend his previous work by testing psychological moderators and studying end of life outcomes. This will be supported by a current R01 (Project 1) and by a planned competitive continuation R01 application (Project 2). (2) To further extend the Pi's research by examining the relationships among depression and specified biological and psychological factors, and their associations with quality of life outcomes and mortality, in older patients with severe heart failure. This new initiative's pilot phase will be followed by an R01-supported study (Project 3). Heart failure is the leading cause of death among older adults, complementing Project 2's 'latter stages of life' theme. (3) To train junior investigators from a range of clinical backgrounds, including physicians, in the design and conduct of geriatric psychiatry studies, particularly those related to depression and medical comorbidity. The application describes the mentoring plans and their feasibility, including the Pi's qualifications, plans for further development of his mentoring skills, and the resources to attract and support trainees. Projects 1-3, and other funded investigations, will be the main research vehicles for such training. Trainees at the Pi's institution will be supported by several existing or pending institutional training grants. The PI also will mentor early career researchers at other institutions through national-level training grants and meetings.

描述（由申请人提供）：本申请为NIMH中期职业研究者奖以患者为导向的研究（K24）要求支持Pi的持续职业发展和作为全国领导者的出现，作为临床研究人员和作为更初级研究人员的导师。调查重点是老年人抑郁症和医学共病的关系，包括它们与生命后期关键生活质量结果的关联。综合研究和指导计划的拟议目标如下： (1)继续发展Pi对初级保健老年人抑郁症和医疗并发症的研究计划，特别是研究未成年人和亚综合征抑郁症的自然历史，并通过测试心理调节剂和研究生命结局来扩展他以前的工作。这将由当前的R 01（项目1）和计划的竞争性延续R 01申请（项目2）提供支持。(2)通过检查抑郁症与特定生物和心理因素之间的关系，以及它们与严重心力衰竭老年患者生活质量结局和死亡率的关系，进一步扩展Pi的研究。这一新举措的试点阶段之后将进行R 01支持的研究（项目3）。心力衰竭是老年人死亡的主要原因，补充了项目2的“生命后期”主题。(3)培训来自一系列临床背景的初级研究人员，包括医生，设计和进行老年精神病学研究，特别是与抑郁症和医疗合并症有关的研究。申请书描述了指导计划及其可行性，包括Pi的资格，进一步发展其指导技能的计划，以及吸引和支持学员的资源。项目1-3和其他资助的调查将是这种培训的主要研究工具。PI机构的受训人员将得到几项现有或即将提供的机构培训赠款的支持。PI还将通过国家级培训赠款和会议指导其他机构的早期职业研究人员。