Betahistine: Novel Therapeutic in Attention Deficit Hyperactivity Disorder

描述(由申请者提供)：本申请申请三个为期三年的研究金名额，通过一个新的机构国家研究服务奖(T32)，支持老年精神病学、心理学和心理健康研究相关领域的博士后培训。我们是在1990年代故意扩大我们部门长期由NIMH资助的T32之后创建这个专门针对老年病的培训计划的，当时我们觉得老年指导小组中的导师太少了。然而，近年来，我们的老年医学研究项目及其合作资源持续大幅增长，从而为翻译研究重点的发展提供了独特的基础。我们的明确目标是将下一代医生和其他受过博士培训的科学家培养成未来的研究人员，进行转化性(即“从床到床”和“临床研究设置到现实世界的实践”)干预和预防研究，主要与晚年的抑郁症和痴呆症有关。我们方法的特点包括接触到广泛的受试者群体(与翻译研究的“真实世界”部分一致)，以及院系和大学范围内的文化，高度重视有指导的职业发展和多学科临床、教育和研究合作。技能发展的核心领域包括：老年精神病病理学、研究设计和方法(特别是与预防和干预研究有关的研究)、生物统计学、出版补助金的编写和撰写以及研究的伦理。有七(7)名职业生涯中期和高级教职员工担任拟议的奖学金名额的主要导师，以及额外的P接收器和资源学院。在过去的15年里，我们系招募了高素质的候选人参加我们的博士后培训计划，我们的受训人员通过他们的出版物、成功资助的拨款申请和晋升，证明了他们的学术生涯是成功的。拟议的培训的基础是建立一种承诺的导师-学员关系，制定让研究员参与当前研究并支持他们自己制定方案的个人定制计划，以及基于教学论的正式学习，包括必修课和选修课、研讨会和研究会议。这种培训解决了老年心理健康研究中严重的“流水线”短缺问题。

DESCRIPTION (provided by applicant): This application presents an application for three 3-year fellowship slots to support postdoctoral training in geriatric psychiatry, psychology, and related areas of mental health research, via a new Institutional National Research Service Award (T32). We are creating this geriatrics-specific training program after the intentional broadening of our Department's longstanding NIMH-funded T32 in the 1990s, when we felt that there were too few mentors in the geriatric mentoring group. In recent years, however, our geriatrics research programs and their collaborative resources have continued to grow substantially, thus providing a unique foundation for the development of a translational research focus. Our explicit goal is to train the next generations of physicians and other doctoral trained scientists as future investigators conducting translational (i.e., "bench to bedside" and "clinical research setting to real world practice") interventions and prevention research, primarily related to depression and dementia in later life. Hallmarks of our approach include access to a wide range of subject populations (consistent with the "real world" component of translational research), and a Departmental and University-wide culture placing high values on mentored career development and on multidisciplinary clinical, educational, and research collaborations. Core areas of skill development include: geriatric psychopathology, research design and methods (particularly as they relate to prevention and intervention research), biostatistics, grant writing and writing for publication, and the ethics of research. There are seven (7) mid-career and senior-level faculty members serving as primary Mentors for the proposed fellowship slots, and additional Preceptors and Resource Faculty. Throughout the past 15 years, our Department has recruited highly qualified candidates to our postdoctoral training programs, and our trainees have gone on to successful academic careers as demonstrated through their publications, their successfully funded grant applications, and their promotions. The proposed training is based on the establishment of a committed mentor-trainee relationship, the formulation of individually tailored programs that involve fellows in current research and support the development of their own protocols, and formal didactics-based learning including both required and "selective" courses, seminars, and research meetings. Such training addresses critical "pipeline" shortages in geriatric mental health research.