Betahistine: Novel Therapeutic in Attention Deficit Hyperactivity Disorder

描述（由申请人提供）：本申请通过新的机构国家研究服务奖（T32）申请三个3年的奖学金名额，以支持老年精神病学，心理学和心理健康研究相关领域的博士后培训。上世纪90年代，我们觉得在老年指导小组中导师太少，于是有意扩大了我们部门长期以来由nimh资助的T32项目，之后我们创建了这个针对老年疾病的培训项目。然而，近年来，我们的老年医学研究项目及其合作资源持续增长，从而为转化研究重点的发展提供了独特的基础。我们的明确目标是培养下一代医生和其他博士培养的科学家作为未来的研究人员进行转化（即“从实验室到床边”和“临床研究环境到现实世界的实践”）干预和预防研究，主要与晚年的抑郁和痴呆有关。我们的方法的特点包括获得广泛的受试者群体（与转化研究的“现实世界”组成部分一致），以及高度重视指导职业发展和多学科临床，教育和研究合作的部门和大学范围的文化。技能发展的核心领域包括：老年精神病理学、研究设计和方法（特别是与预防和干预研究有关的研究）、生物统计学、拨款写作和出版写作以及研究伦理。有七(7)名职业生涯中期和高级教师担任拟议奖学金名额的主要导师，以及额外的导师和资源教师。在过去的15年里，我们的部门招募了高素质的候选人参加我们的博士后培训计划，我们的学员已经通过他们的出版物，他们成功的资助申请和他们的晋升证明了他们成功的学术生涯。拟议的培训是基于建立一种承诺的导师-学员关系，制定个性化的计划，让研究员参与当前的研究并支持他们自己的协议的发展，以及正式的基于教学的学习，包括必修和“选择性”课程，研讨会和研究会议。这种培训解决了老年心理健康研究中严重的“管道”短缺问题。

DESCRIPTION (provided by applicant): This application presents an application for three 3-year fellowship slots to support postdoctoral training in geriatric psychiatry, psychology, and related areas of mental health research, via a new Institutional National Research Service Award (T32). We are creating this geriatrics-specific training program after the intentional broadening of our Department's longstanding NIMH-funded T32 in the 1990s, when we felt that there were too few mentors in the geriatric mentoring group. In recent years, however, our geriatrics research programs and their collaborative resources have continued to grow substantially, thus providing a unique foundation for the development of a translational research focus. Our explicit goal is to train the next generations of physicians and other doctoral trained scientists as future investigators conducting translational (i.e., "bench to bedside" and "clinical research setting to real world practice") interventions and prevention research, primarily related to depression and dementia in later life. Hallmarks of our approach include access to a wide range of subject populations (consistent with the "real world" component of translational research), and a Departmental and University-wide culture placing high values on mentored career development and on multidisciplinary clinical, educational, and research collaborations. Core areas of skill development include: geriatric psychopathology, research design and methods (particularly as they relate to prevention and intervention research), biostatistics, grant writing and writing for publication, and the ethics of research. There are seven (7) mid-career and senior-level faculty members serving as primary Mentors for the proposed fellowship slots, and additional Preceptors and Resource Faculty. Throughout the past 15 years, our Department has recruited highly qualified candidates to our postdoctoral training programs, and our trainees have gone on to successful academic careers as demonstrated through their publications, their successfully funded grant applications, and their promotions. The proposed training is based on the establishment of a committed mentor-trainee relationship, the formulation of individually tailored programs that involve fellows in current research and support the development of their own protocols, and formal didactics-based learning including both required and "selective" courses, seminars, and research meetings. Such training addresses critical "pipeline" shortages in geriatric mental health research.