Finding new antibiotics in the soil microbiota

抗药性细菌感染的增加是一个主要的全球健康威胁。这一危机因缺乏新的抗生素而加剧，这是由多种因素造成的，包括已知抗生素的频繁重新发现。土壤微生物群是天然产物分子的丰富来源，土壤细菌产生大多数当前临床抗菌剂。土壤微生物群中巨大的遗传多样性意味着许多新的、临床相关的天然产物无疑仍有待鉴定。然而，为了充分利用这一自然资源，需要鉴定有效的抗菌剂，并有效地最大限度地减少再发现。该项目旨在振兴抗生素管道，并指导新抗生素类别的发现。约翰英纳斯中心开发了一个有效的，高通量的管道，用于鉴定和表征生物有效的细菌天然产物。通过将抗生素发现与先进的数据分析相结合，确保优先考虑新的途径和产品，并最大限度地减少抗生素的重新发现。该项目将利用广泛的土壤微生物分离库和最近研究中出现的发现管道，以识别和鉴定新的临床有效的抗菌分子。

The increase in drug-resistant bacterial infections is a major global health threat. This crisis is exacerbated by a lack of new antibiotics, caused by multiple factors including the frequent rediscovery of known antibiotics. The soil microbiota is a rich source of natural product molecules, with soil bacteria producing the majority of current clinical antimicrobials. The vast genetic diversity within the soil microbiota means that many novel, clinically relevant natural products undoubtedly remain to be identified. However, to fully exploit this natural resource efficacious antimicrobials both need to be identified and rediscovery effectively minimised. The project seeks to revitalise the antibiotic pipeline and guide the discovery of new antibiotic classes.The John Innes Centrehas developed an effective, high-throughput pipeline for the identification and characterisation of biologically effective bacterial natural products. By pairing antimicrobial discovery with advanced data analysis it is ensured that novel pathways and products are prioritised, and antibiotic rediscovery minimised. The project will exploit the extensive soil microbial isolate libraries and discovery pipeline emerging from recent research to identify and characterise new, clinically efficacious antimicrobial molecules.