Towards the sustainable discovery and development of new antibiotics

迈向新抗生素的可持续发现和开发

• 批准号: FT230100468
• 负责人: Dr Zeinab Khalil
• 金额: $ 51.99万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100468
• 关键词: Towards; sustainable; discovery; development; new

This project aims to define how to access silent biosynthetic genes within microbial genome to facilitate access to new chemical diversity hidden within microbial genomes. Using interdisciplinary approaches in genome mining and metabolomics technologies, the project expects to inspire and enable the future design of more effective antibiotics. Expected outcomes from this program include define new microbial defence molecules, to meet future demands in agrochemical and environmental sciences. It will also train future scientists and develop international collaborations. This should provide significant benefit, including a higher-quality workforce for research and innovation, positioning Australia at the forefront of drug discovery.

该项目旨在确定如何获取微生物基因组中沉默的生物合成基因，以促进获取隐藏在微生物基因组中的新化学多样性。利用基因组挖掘和代谢组学技术的跨学科方法，该项目希望激发并使未来设计更有效的抗生素成为可能。该计划的预期成果包括定义新的微生物防御分子，以满足农业化学和环境科学的未来需求。它还将培训未来的科学家并发展国际合作。这将带来巨大的好处，包括为研究和创新提供更高质量的劳动力，使澳大利亚处于药物发现的前沿。