The Adverse Effect of Health on Personal Goal Pursuit in Adolescents with Cancer

描述（由申请人提供）：在青春期，个人在设定和追求对他们的福祉和向成年过渡至关重要的个人目标方面变得越来越自主。当癌症发生在青春期时，这些关键的发育过程可能会受到损害。很少有研究表明青少年患癌症的影响，也没有研究专门评估健康对青少年癌症患者追求个人目标的影响。然而，一些对患有慢性病的成年人的研究已经衡量了健康对个人目标追求的影响（即。与健康有关的障碍）以及随后对福祉的不利影响。因此，评估青少年癌症患者的健康障碍是了解癌症在青春期的不利影响的创新方法。此外，了解癌症青少年目标追求受阻的潜在风险和弹性因素将突出干预目标，以帮助青少年继续追求对他们的福祉和向成年过渡至关重要的目标。该研究的具体目的是证明与健康有关的障碍与青少年幸福的关系，评估青少年与癌症和非癌症之间的差异与健康有关的障碍，并确定与疾病相关的风险因素和社会心理弹性因素与HRH在青少年癌症。将从13至19岁的青少年癌症患者和从未患病的对照组中收集问卷数据。这项研究与NCI的目标是一致的，即增加对青少年的研究，了解诊断的不良结果，并确定促进弹性的方法。本研究的长期目标是为未来的纵向研究提供信息，研究与健康相关的目标障碍对幸存者的影响，并进行干预研究，以提高青少年和成年早期的弹性。与公共卫生的相关性：青春期癌症较常见，发病率比儿童增长更快。幸运的是，儿童癌症的10年生存率接近75%，这在短短几十年内急剧增加。对幸存者心理社会结果的研究也有所增加，并发现：（1）儿童癌症幸存者的心理健康和生活质量比对照样本更差，（2）他们可能难以实现与教育，职业，人际关系和父母个性化相关的发展里程碑。然而，研究尚未将特定发育时期的诊断与后来的心理社会结果联系起来。拟议的研究计划证明癌症对青春期个人目标追求的重要影响，这将成为未来相关研究的基础，将青春期与健康相关的目标障碍与儿童癌症幸存者的不良后果联系起来。

DESCRIPTION (provided by applicant): During adolescence, individuals become increasingly autonomous in setting and pursuing personal goals that are important for their well-being and transition to adulthood. When cancer occurs during adolescence, these critical developmental processes may be compromised. Little research has demonstrated the impact of having cancer in adolescence and no research has specifically assessed the impact of health on pursuit of personal goals in adolescents with cancer. However, some research with adults with chronic illness has measured the impact of health on personal goal pursuit (i.e.. health-related hindrance) and the subsequent adverse effects on well-being. Thus, assessing the health-related hindrance of adolescents with cancer is an innovative approach to understanding the adverse impact of cancer during adolescence. Additionally, understanding potential risk and resilience factors of hindered goal pursuit of adolescents with cancer will highlight targets of intervention to help adolescents continue to pursue goals that are important for their well- being and transition to adulthood. The specific aims of the study are to demonstrate the relationship of health-related hindrance to adolescent well-being, evaluate differences among adolescents with and without cancer with respect to health-related hindrance, and identify disease-related risk factors and psychosocial resilience factors related to HRH in adolescents with cancer. Questionnaire data will be collected from adolescents with cancer ages 13 to 19 and never ill matched controls. The study is compatible with goals of the NCI to increase research with adolescents, understand adverse outcomes of diagnosis, and identify ways to promote resiliency. Long-term goals of this study are to inform future longitudinal research on the impact of health-related hindrance of goals in survivors and intervention research to enhance resiliency in adolescence and early adulthood. Relevance to Public Health: Cancer in adolescence is more common and the rate of incidence has increased more rapidly than that of children. Fortunately, the 10-year survival rate of pediatric cancer is approaching 75%, which represents a dramatic increase in just a few decades. Research on psychosocial outcomes of survivors has also increased and has found that: (1) childhood cancer survivors are more likely to have worse mental health and quality of life than control samples and (2) they may experience difficulty achieving developmental milestones related to education, career, interpersonal relationships, and individuation from parents. However, research has not yet linked diagnosis during a specific developmental period and later psychosocial outcomes. The proposed research plans to demonstrate the important impact of cancer on personal goal pursuit during adolescence, which will be the basis for future related research linking health-related hindrance of goals in adolescence to later adverse outcomes for childhood cancer survivors.