Regional Biocontainment Laboratory

区域生物防护实验室

• 批准号: 7005612
• 负责人: JAMES R GAINES
• 金额: $ 2499.96万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-06 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7005612
• 关键词: Hawaii; behavioral /social science research tag; biological models; biomedical facility; bioterrorism /chemical warfare; building /facility design /renovation; cooperative study; disease outbreaks; emerging infectious disease; tissue /cell culture

DESCRIPTION (provided by applicant): Located approximately 4,000 km from both North America and the islands of Polynesia in the middle of the Pacific Ocean, Hawaii serves as a principal U.S. gateway to and from Asia, and as a major tourist destination for people worldwide. It is also home to some of the Nation's most strategic Army, Navy, Air Force and Marine Corps military bases. Because of the heavy tourist traffic from Asia and elsewhere, and the presence of military forces, Hawaii is at high risk for natural and deliberate introductions of exotic infectious diseases. Against this backdrop, containment laboratories for select agents and other human pathogens are woefully inadequate in Hawaii. Thus, in response to the global resurgence of new, emerging and re-emerging infectious diseases in the Asia-Pacific region, and to fulfill the needs to significantly improve the physical infrastructure for bioterrorism preparedness and response and for emerging infectious diseases research, this application from the University of Hawaii proposes to build the Pacific Regional Biocontainment Laboratory (PacRBL), a 70,000-gross square foot, stand-alone containment facility with suitably equipped spaces for research on select agents using cell-culture systems and animal models in rodents and nonhuman primates. By drawing on the complementary strengths and resources within the University of Hawaii, as well as from state and federal agencies (including the State of Hawaii Department of Health, the U.S. Pacific Command, and Tripler Army Medical Center), and the private sector (Hawaii Biotech, Inc.), the PacRBL will be anchored by the tenets of public health and of trans-disciplinary and translational research. Adequate matching funds for this high-priority initiative are in place, and research funding from NIAID and other federal agencies and private foundations, secured by the lead institution and its partners, fully justify the construction of a regional biocontainment laboratory. In turn, the availability of the proposed multi-user, state-of-the-art facility will help to expand and diversify the research portfolio on biodefense and emerging infectious diseases for the State of Hawaii. Moreover, the PacRBL will serve as a regional resource for national and international bioterrorism emergencies and as a reference diagnostic center for outbreaks of newly recognized infectious diseases originating in the Asia-Pacific Region.

描述（由申请人提供）： 夏威夷距离北美和波利尼西亚群岛约4,000公里，是美国往返亚洲的主要门户，也是全球人民的主要旅游目的地。它也是美国一些最战略战略，海军，空军和海军陆战队军事基地的所在地。由于来自亚洲和其他地方的旅游流量大量以及军事力量的存在，夏威夷的自然和故意引入异国情调的传染病的风险很高。在这种背景下，夏威夷的精选药物和其他人类病原体的遏制实验室严重不足。 Thus, in response to the global resurgence of new, emerging and re-emerging infectious diseases in the Asia-Pacific region, and to fulfill the needs to significantly improve the physical infrastructure for bioterrorism preparedness and response and for emerging infectious diseases research, this application from the University of Hawaii proposes to build the Pacific Regional Biocontainment Laboratory (PacRBL), a 70,000-gross square foot,独立的遏制设施，具有适当配备的空间，可用于研究啮齿动物和非人类灵长类动物中的细胞培养系统和动物模型。 通过利用夏威夷大学内的补充优势和资源，以及州和联邦机构（包括夏威夷卫生部，美国太平洋司令部和三军陆军医疗中心）和私营部门（夏威夷生物技术，Inc。），PACR将由公共卫生和经济学上和翻译学研究的原则固定。这项高优先倡议的足够匹配资金已经到位，由NIAID和其他联邦机构以及由领先机构及其合作伙伴确保的研究资金充分证明了区域生物自然实验室的建设是合理的。反过来，拟议的多用户最先进的设施的可用性将有助于扩大和多样化夏威夷州生物探讨和新兴传染病的研究组合。此外，PACRBL将成为国家和国际生物恐怖主义紧急情况的区域资源，并作为源自亚太地区的新认可的传染病爆发的参考诊断中心。