Regional Biocontainment Laboratory

区域生物防护实验室

• 批准号: 7490782
• 负责人: JAMES R GAINES
• 金额: $ 750万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-06 至 2013-01-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7490782
• 关键词: Air; Animal Model; Arts; Asia; Bioterrorism; Cell Culture System; Communicable Diseases; Containment; Destinations; Diagnostic; Disease Outbreaks; Emergency Situation; Emerging Communicable Diseases; Facility Construction Funding Category; Foundations; Funding; Hawaii; Health; Home environment; Human; Infectious Diseases Research; Institution; International; Island; Laboratories; Lead; Marines; Medical center; Military Personnel; National Institute of Allergy and Infectious Disease; North America; Pacific Ocean; Polynesia; Private Sector; Public Health; Readiness; Research; Research Infrastructure; Resources; Risk; Rodent; Secure; Translational Research; Universities; base; biodefense; foot; improved; nonhuman primate; pathogen; response; trafficking

Located approximately 4,000 km from both North America and the islands of Polynesia in the middle of the Pacific Ocean, Hawaii serves as a principal U.S. gateway to and from Asia, and as a major tourist destination for people worldwide. It is also home to some of the Nation's most strategic Army, Navy, Air Force and Marine Corps military bases. Because of the heavy tourist traffic from Asia and elsewhere, and the presence of military forces, Hawaii is at high risk for natural and deliberate introductions of exotic infectious diseases. Against this backdrop, containment laboratories for select agents and other human pathogens are woefully inadequate in Hawaii. Thus, in response to the global resurgence of new, emerging and re-emerging infectious diseases in the Asia-Pacific region, and to fulfill the needs to significantly improve the physical infrastructure for bioterrorism preparedness and response and for emerging infectious diseases research, this application from the University of Hawaii proposes to build the Pacific Regional Biocontainment Laboratory (PacRBL), a 70,000-gross square foot, stand-alone containment facility with suitably equipped spaces for research on select agents using cell-culture systems and animal models in rodents and nonhuman primates. By drawing on the complementary strengths and resources within the University of Hawaii, as well as from state and federal agencies (including the State of Hawaii Department of Health, the U.S. Pacific Command, and Tripler Army Medical Center), and the private sector (Hawaii Biotech, Inc.), the PacRBL will be anchored by the tenets of public health and of trans-disciplinary and translational research. Adequate matching funds for this high-priority initiative are in place, and research funding from NIAID and other federal agencies and private foundations, secured by the lead institution and its partners, fully justify the construction of a regional biocontainment laboratory. In turn, the availability of the proposed multi- user, state-of-the-art facility will help to expand and diversify the research portfolio on biodefense and emerging infectious diseases for the State of Hawaii. Moreover, the PacRBL will serve as a regional resource for national and international bioterrorism emergencies and as a reference diagnostic center for outbreaks of newly recognized infectious diseases originating in the Asia-Pacific region.

位于距北美和波利尼西亚岛的约4,000公里处 夏威夷太平洋是往返亚洲的主要门户，作为主要的游客 全球人的目的地。它也是美国一些战略性军队，海军，空中的所在地 部队和海军陆战队军事基地。由于来自亚洲和其他地方的旅游流量很大，以及 军事力量的存在，夏威夷有天然和故意介绍异国的风险 传染病。在此背景下，适用于精选代理商和其他人的遏制实验室 在夏威夷，病原体严重不足。因此，为了回应全球新的复兴 亚太地区的新兴和重新出现传染病，并满足需求 显着改善了生物恐怖主义准备和反应的物理基础设施以及 新兴的传染病研究，夏威夷大学的申请提议建立 太平洋地区生物疗养实验室（PACRBL），一个70,000平方英尺，独立的 围栏设施具有适当设备齐全的空间，可用于使用细胞培养系统对精选代理进行研究 以及啮齿动物和非人类灵长类动物的动物模型。 通过利用夏威夷大学内的互补优势和资源以及 州和联邦机构（包括夏威夷卫生部，美国太平洋卫生部 司令部和三倍陆军医疗中心）和私营部门（夏威夷生物技术公司），PACRBL 将由公共卫生和跨学科和翻译研究的宗旨锚定。 这项高优先倡议的足够匹配资金已经到位，Niaid和 其他联邦机构和私人基金会，由牵头机构及其合作伙伴确保 建造区域生物设备实验室。反过来，拟议的多 用户，最先进的设施将有助于扩展和多样化生物浮雕的研究组合 夏威夷州的新兴传染病。此外，PACRBL将充当区域 国家和国际生物恐怖主义的资源紧急情况，并作为参考诊断中心 起源于亚太地区的新认可的传染病的爆发。