Graph Representation Learning for Biomedical Entities

生物医学实体的图表示学习

• 批准号: 2751532
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2751532
• 关键词: Graph; Representation; Learning; Biomedical; Entities

Graph representation learning has rapidly become one of the main drivers in machine learning research over recent years. The power of graph representation lies in its ability to naturally represent entities and their interactions. Incorporating in machine learning models the inductive bias contained in the graph-structured representation of the data, has led to significant advances in many areas of research. Biomedical research has particularly benefited of graph representation learning methodologies, since networks can be used to represent a multitude of biological entities and their associations. These applications and methodologies aim to find appropriate representations of biological networks for different tasks. However, it is still unclear how to effectively combine information originated from different networks. Drug development, analysis of disease progression, therapeutic response design and several more tasks require considering the complex relationships within and among several biological networks. Traditional network representations are insufficient for dealing with the heterogeneity of objects and relationships, so a richer framework is needed to handle objects and relationships of different scales. This proposal aims to develop new graph representation learning methods that can integrate and explain complex, multiplex, and multilayer networks where nodes and edges have different meanings.

近年来，图表示学习已迅速成为机器学习研究的主要驱动力之一。图形表示的强大之处在于它能够自然地表示实体及其交互。在机器学习模型中解释数据的图形结构表示中包含的归纳偏差，已经在许多研究领域取得了重大进展。生物医学研究特别受益于图形表示学习方法，因为网络可以用来表示大量的生物实体及其关联。这些应用程序和方法的目的是找到适当的生物网络的不同任务的表示。但是，如何有效地将源自不同网络的联合收割机信息组合起来，目前还不清楚。药物开发、疾病进展分析、治疗反应设计和其他一些任务需要考虑几个生物网络内部和之间的复杂关系。传统的网络表示不足以处理对象和关系的异构性，因此需要一个更丰富的框架来处理不同尺度的对象和关系。该提案旨在开发新的图形表示学习方法，可以集成和解释节点和边缘具有不同含义的复杂，多重和多层网络。