Developmental Immunotherapeutics-Allergic Disease/Asthma

嗜酸性粒细胞性胃肠道疾病，包括嗜酸性粒细胞性胃肠炎和嗜酸性粒细胞性食管炎，通常与食物和空气过敏原过敏有关。这些患者中有许多食物过敏，表明这种疾病实体代表了黏膜耐受性失调的一个例子。我们目前正在招募治疗嗜酸性胃肠炎的omalizumab（治疗性单克隆抗ige）临床试验的受试者。本研究结果将为抗ige治疗嗜酸性胃肠道疾病的临床应用提供信息。此外，该结果将为IgE介导的过程（即时超敏反应、肥大细胞和嗜碱性粒细胞活化）在嗜酸性胃肠道疾病发病机制中的作用提供数据。进一步了解嗜酸性胃肠道疾病将为今后的治疗策略提供基础。

Eosinophilic gastrointestinal diseases, including eosinophilic gastroenteritis and eosinophilic esophagitis, commonly associated with food and aeroallergen hypersensitivity. Many of these patients have numerous food allergies, suggesting this disease entity represents an example of dysregulated mucosal tolerance. We are currently enrolling subjects in a clinical trial of omalizumab (therapeutic monoclonal anti-IgE) for eosinophilic gastroenteritis. The results of this study will yield information on the clinical utility of anti-IgE therapeutics in eosinophilic gastrointestinal diseases. Additionally, the results will provide data on the role of IgE mediated processes (immediate hypersensitivity, mast cell and basophil activation) in the pathogenesis of eosinophilic gastrointestinal diseases. Greater understanding of eosinophilic gastrointestinal diseases will provide a basis for future therapeutic strategies. Airway inflammation is central to asthma pathogenesis, and all guidelines for asthma therapy recommends anti-inflammatory therapy for all but the mildest asthma patients. Despite this, there are currently no clinically available non-invasive tests to measure airway inflammation in asthma. We currently are enrolling subjects in a clinical study utilizing exhaled breath condensate as a non-invasive technique to measure airway inflammation in pediatric patients. The results of this study will contribute to the development of non-invasive tools to measure and clinically manage asthmatic airway inflammation.