Physical Activity Monitoring In the LIFE Study Using the

生命研究中的身体活动监测使用

• 批准号: 7135639
• 负责人: Jack M Guralnik
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON AGING
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7135639
• 关键词: actigraphy; body physical activity; clinical trials; exercise; gait; human subject; monitoring device; questionnaires

The major intervention in the LIFE pilot study for participants assigned to the exercise group will be walking. According to the treatment protocol, during the first six months as much as half of their increase in walking will be carried out ?at home? or in a non-supervised setting. During the second six months, at least 75% of the assigned walking will be non-supervised for most participants. To know if this intervention was accomplished, LIFE investigators need documentation that a significant increase in walking took place in the exercise participants versus the healthy aging class participants. Currently the protocol includes the use of pedometers, logs and the CHAMPS questionnaire to inform the investigators about the activity profile of each study participant. While all of these measurement tools are likely to provide useful data, none have been proven to provide an accurate and objective assessment of the daily physical activity profile of older, somewhat frail persons. The Actigraph is a small solid-state accelerometer/recorder (6.6 x 4.3 x 2.5 cm., 70 grams) that can store the number of times it moves x the rate of movement change (acceleration) on a continuous basis for up to a month (approximate battery life). It stores these ?counts? for specified times intervals, usually set at one-minute. For LIFE, this monitor will be worn on the right hip of each participant. The specific aims of this project are to determine the capability of the Actigraph accelerometer activity monitor to detect a significant difference in the physical activity level in a subset of subjects assigned to the LIFE exercise group versus the healthy aging class controls at six months into the study, (2) compare the assessment of amount of physical activity performed by a subset of subjects in the two treatment groups as determined by the CHAMPS physical activity questionnaire administered at 6 months and the Actigraph monitor using average number of ?accelerometer counts? per hour and number of minutes per day spent above a conditioning threshold, and (3) determine if data collected by the Actigraph monitor during the 400-meter walk at the 6-month evaluation can be used to help ?calibrate? or individualize the analysis of the Actigraph recorded during the 7 days of usual living.

在LIFE试点研究中，被分配到运动组的参与者的主要干预措施将是步行。根据治疗方案，在头六个月内，他们增加的一半步行将进行？在家吗或在无监督的环境中。在接下来的六个月里，大多数参与者至少有75%的指定步行将是无人监督的。为了知道这种干预是否完成，LIFE研究人员需要证明运动参与者与健康老龄化参与者相比，步行量显着增加。目前，该方案包括使用计步器，日志和CHAMPS问卷，以告知研究人员每个研究参与者的活动概况。虽然所有这些测量工具都可能提供有用的数据，但没有一个被证明可以对老年人的日常身体活动情况提供准确和客观的评估，有些虚弱的人。Actigraph是一种小型固态加速计/记录仪（6.6 x 4.3 x 2.5 cm，70克），可以连续存储它移动的次数x移动变化率（加速度）长达一个月（近似电池寿命）。它能储存这些？算吗对于指定的时间间隔，通常设置为一分钟。对于LIFE，该监护仪将佩戴在每名受试者的右髋关节上。 本项目的具体目的是确定Actigraph加速度计活动监测仪检测LIFE运动组受试者子集与健康老龄化对照组受试者子集在研究6个月时身体活动水平的显著差异的能力，（二）比较两个治疗组中受试者子集进行的体力活动量评估（通过CHAMPS体力活动问卷确定）在6个月时给药，并使用Actigraph监测器的平均数量？加速度计算吗每小时和每天超过调节阈值的分钟数，以及（3）确定在6个月评估时400米步行过程中活动图监测仪收集的数据是否可以用于帮助？校准？或对7天日常生活中记录的活动记录仪进行个性化分析。