Biomechanical Basis for Treatment of Cartilage defects

软骨缺损治疗的生物力学基础

• 批准号: 7156450
• 负责人: Won C Bae
• 金额: $ 4.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7156450
• 关键词: articular cartilage; cartilage; human; joints

DESCRIPTION: Articular cartilage functions as a load-bearing, low-friction, wear-resistant padding in joints. Osteoarthritis is a joint disease that often involve occurrence of cartilage defects (local loss of cartilage), which can enlarge if left untreated. Therefore, treatment strategies have been proposed to either restore cartilage or prevent further degeneration. Most of such strategies are biological in nature, aiming to recruit or embed cells that could regenerate cartilage. However, a biomechanical basis for defect progression or repair has not been explored in detail. While it seems likely that a joint containing a cartilage defect would have diminished capacity to bear load and to provide a low-friction surface, such biomechanical sequelae have been neither assessed in detail, nor considered as the targets of cartilage repair strategies. Therefore, this proposal seeks to 1) determine the effects of focal defects on cartilage load-bearing and friction, and 2) establish biomechanical concepts for effective repair that can be combined with existing methods. Also, MRI-based methods to assess effects of cartilage defects on joint function will be developed. Achievement of the project aims will advance the understanding of cartilage degeneration in arthritis, and provide targets for diagnosis and treatment of cartilage defects.

描述：关节软骨在关节中起着承重、低摩擦、耐磨的作用。骨关节炎是一种关节疾病，通常涉及软骨缺陷（局部软骨缺失）的发生，如果不及时治疗，软骨缺陷可能会扩大。因此，已提出治疗策略来恢复软骨或防止进一步退化。大多数这样的策略本质上是生物学的，旨在招募或嵌入可以再生软骨的细胞。然而，尚未详细探讨缺损进展或修复的生物力学基础。虽然含有软骨缺损的关节似乎可能会降低承受载荷和提供低摩擦表面的能力，但这种生物力学后遗症既没有详细评估，也没有被认为是软骨修复策略的目标。因此，本提案寻求 1）确定局灶性缺损对软骨承重和摩擦的影响，以及2）建立 有效修复的生物力学概念可以与现有方法相结合。此外，将开发基于MRI的方法来评估软骨缺损对关节功能的影响。该项目目标的实现将促进对关节炎中软骨退变的认识，并为软骨缺损的诊断和治疗提供靶点。