Ultrashort Time to Echo MRI of Disco Vertebral Junction

迪斯科椎体交界处的超短时间回波 MRI

• 批准号: 8886674
• 负责人: Won C Bae
• 金额: $ 34.1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2020-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8886674
• 关键词: Affect; Age; Aging; Attention; Biochemical; Biochemistry; Biomechanics; Blood Vessels; Characteristics; Clinical; Collagen; Diffusion; Disease; Evaluation; Exhibits; Fatty acid glycerol esters; Foundations; GAG Gene; Goals; Histology; Histopathology; Human; Imaging Techniques; Intervertebral disc structure; Lead; Link; Low Back Pain; Magnetic Resonance; Magnetic Resonance Imaging; Marrow; Measures; Morphology; Nutrient; Pathologic; Pathology; Pathway interactions; Patients; Play; Population; Property; Puncture procedure; Role; Sampling; Signal Transduction; Spinal Fractures; Staining method; Stains; Structure; Techniques; Testing; Thick; Time; Tissues; Translating; Vertebral column; Water; Work; bone; calcification; cost; human subject; in vivo; indexing; intervertebral disk degeneration; microCT; non-invasive imaging; nutrition; public health relevance; research study; socioeconomics; solute; spine bone structure; tool; vertebra body

 DESCRIPTION (provided by applicant): Low back pain is a multi-factorial disease with high socioeconomic cost. Conditions including degeneration of intervertebral discs (IVD), pathology of vertebral body, and fracture of vertebral endplate all are closely associated with low back pain. Disco-vertebral junction is the interface between the IVD and vertebral body, and plays important roles in nutrition of the IVD via vascular canals in the adjacent vertebral body, as well as in biomechanical support during loading. Abnormal changes in structure, composition and function of the DVJ may occur in diseases and aging, which may hinder nutrient transport and lead to IVD degeneration, as well as degeneration of the vertebral body. The long-term goal of this study is to establish a non-invasive imaging technique for a comprehensive evaluation of the whole lumbar spine. While magnetic resonance imaging (MRI) has been used routinely, conventional MR techniques such as spin echo sequence are unable to detect sufficient MR signal from the DVJ, and little is known about MR characteristics of the region. We have recently shown in that Ultrashort Time-to-Echo (UTE) MRI, but not conventional MRI, is able to evaluate the DVJ directly in human lumbar spines. As the next step, we seek to determine if UTE MRI can detect abnormal and pathologic changes in structure, composition, transport-function the DVJ, which may be related to degeneration of the IVD and vertebral body. Finally, we seek to translate the techniques to evaluate the DVJ, IVD, and vertebral body in normal and low back pain human subjects. This study will establish the foundation and rationale for UTE MR evaluation of the DVJ, and help to better understand pathoetiology of disc degeneration.

 描述（由申请人提供）：腰痛是一种多因素疾病，具有很高的社会经济成本。椎间盘退变、椎体病理、椎体终板骨折等病症均与腰痛密切相关。椎间盘连接处是 IVD 与椎体之间的界面，通过邻近椎体的血管管对 IVD 的营养起着重要作用。 如加载期间的生物力学支撑。疾病和衰老可能会导致DVJ的结构、组成和功能发生异常变化，从而阻碍营养物质运输并导致IVD变性以及椎体退变。本研究的长期目标是建立一种对整个腰椎进行综合评估的非侵入性成像技术。虽然磁共振成像 (MRI) 已被常规使用，但传统的 MR 技术（例如自旋回波序列）无法从 DVJ 检测到足够的 MR 信号，并且对该区域的 MR 特性知之甚少。我们最近表明，超短回波时间 (UTE) MRI（而非传统 MRI）能够直接评估人体腰椎中的 DVJ。下一步，我们试图确定 UTE MRI 是否可以检测 DVJ 结构、成分、运输功能的异常和病理变化，这些变化可能与 IVD 和椎体的退变有关。最后，我们寻求转化技术来评估正常和腰痛人类受试者的 DVJ、IVD 和椎体。本研究将为 DVJ 的 UTE MR 评估奠定基础和基本原理，并有助于更好地了解椎间盘退变的病理学。