CT and FTIR Assessment of Bone Structure and Composition

描述(由申请人提供)：最新一代的微型计算机断层扫描(MicroCT)扫描仪，结合了改进的射束硬化校正，有可能同时评估微结构和组织矿化。第二种新出现的骨成分分析方法是傅立叶变换红外显微光谱成像(FTIRI)，它提供了矿化和矿物质量的补充空间测量。该建议的目的是开发一种同时评估骨小梁结构和成分的方法，该方法结合基于MicroCT的3D矿化数据和FTIRI获得的2D成分信息，并利用该方法来研究人类骨质疏松进展的影响。矿化措施和形态特征之间的关系将被调查。一旦建立，这项技术将在骨质量研究中提供一个强大的工具，例如量化与年龄、疾病或药物治疗相关的矿化变化，确定与骨翻转机制相关的空间矿化模式，或探索矿物质质量、组织损伤和骨强度之间的关系。

DESCRIPTION (provided by applicant): The newest generation of micro computed tomography (microCT) scanners, incorporating improved beam- hardening corrections, have the potential to provide simultaneous assessment of both micro-architecture and tissue mineralization. A second emerging modality for bone composition analysis is Fourier transform infrared microspectroscopic imaging (FTIRI), which provides complementary spatial measures of mineralization and mineral quality. The objective of this proposal is to develop a method for the simultaneous assessment of trabecular bone structure and composition incorporating microCT-based 3D mineralization data and FTIRI-derived 2D compositional information, and to utilize this method to investigate the effects of osteoporosis progression in human subjects. Relationships among mineralization measures and morphological features will be investigated. Once established, this technique will provide a powerful tool in bone quality studies, for example in quantifying changes in mineralization associated with age, disease, or drug treatment, determining spatial mineralization patterns associated with bone turn-over mechanisms, or exploring relationships between mineral quality, tissue damage, & bone strength.