Integrated Biochemo-catalysis for Asymmetric Arylation

不对称芳基化的集成生物化学催化

• 批准号: 2752680
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2752680
• 关键词: Integrated; Biochemo; catalysis; Asymmetric; Arylation

The integration of chemo- and biocatalysis offers a sustainable approach to making molecules which enables waste-free synthesis, catalytic or metal-free alternatives to current reagents, and a new way of building up molecular complexity whilst simplifying process complexity and cost. Approaching synthesis from this perspective will be critical to future chemistry, where all inter-related factors (reagents, solvent, yields, intermediates, catalysts etc) can be systemically optimized for the best synthetic route. The challenges, however, are substantial - how can we create mutually compatible reaction conditions for both enzymes and chemo systems, given the often vastly different requirements (notably of temperature and solvent)?The integration of chemocatalysis and biocatalysis represents an emerging area of research that will be central to the future chemical and manufacturing industries, activities that are crucial to the welfare and operation of our society. The two regimes of catalysis are highly complementary, with chemocatalysis offering powerful C-C bond strategies that can be merged with asymmetric functional group transformations controlled by an enzyme - an approach that is inspired by the ideality of biosynthesis. Arylation without recourse to precious metal catalysis is challenging and highly influential to current thinking in chemistry, creating high impact publications for the iCAT student engaged on the project. The project will provide training in areas such as biocatalysis, photoredox catalysis, organocatalysis, protein expression and purification, biological assay, asymmetric synthesis, and aqueous chemistry, meeting the mission statement of the CDT to create the next generation of scientist who can operate across the chemical continuum and is equipped for future Leadership roles in a changing, agile industry. The project has grown from a long-standing collaboration between the Greaney and Turner laboratories in integrated catalysis that has produced advances in bio-redox and C-H arylation, providing a supportive framework of co-workers, equipment and ideas in which the iCAT student can realise the ambitious goals of the research. Both the Turner and Greaney groups collaborate extensively with industrial groups (e.g. Syngenta, AZ, GSK) around the arylation and biocatalysis transformation concepts set out in the proposal, bringing end-user interactions to the project and helping the student create a scientific network in the early stages of their research career.

化学催化和生物催化的结合提供了一种制造分子的可持续方法，使现有试剂的无废物合成、催化或无金属替代品成为可能，并提供了一种在简化过程复杂性和成本的同时建立分子复杂性的新方法。从这个角度探讨合成将对未来的化学至关重要，在未来的化学中，所有相互关联的因素(试剂、溶剂、产率、中间体、催化剂等)都可以系统地优化，以获得最佳的合成路线。然而，挑战是巨大的--我们如何为酶和化学系统创造相互兼容的反应条件，因为两者的要求往往截然不同(尤其是温度和溶剂)？化学催化和生物催化的整合代表着一个新兴的研究领域，它将对未来的化学和制造业至关重要，这些活动对我们社会的福利和运行至关重要。这两种催化体系是高度互补的，化学催化提供了强大的C-C键策略，可以与酶控制的不对称官能团转化相结合-这一方法受到生物合成的理想性的启发。不求助于贵金属催化的芳基化对化学中的当前思维具有挑战性和极大的影响力，为从事该项目的ICAT学生创造了高影响力的出版物。该项目将在生物催化、光氧化还原催化、有机催化、蛋白质表达和纯化、生物分析、不对称合成和水化学等领域提供培训，满足CDT的使命声明，培养能够跨化学连续体进行操作的下一代科学家，并为未来在变化的、灵活的行业中发挥领导作用做好准备。该项目源于Greaney和Turner实验室在集成催化方面的长期合作，在生物氧化还原和C-H芳基化方面取得了进展，为ICAT学生实现雄心勃勃的研究目标提供了一个由同事、设备和想法组成的支持性框架。特纳和Greaney团队都与工业集团(如先正达、AZ、葛兰素史克)围绕提案中提出的芳基化和生物催化转化概念进行了广泛的合作，将最终用户的互动带到了项目中，并帮助学生在研究生涯的早期阶段建立了一个科学网络。