The Study of Task-Level Control Signals Using fMRI

利用功能磁共振成像研究任务级控制信号

• 批准号: 7082015
• 负责人: STEVEN E. PETERSEN
• 金额: $ 35.48万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7082015
• 关键词: auditory stimulus; behavior test; bioimaging /biomedical imaging; brain mapping; clinical research; cognition; frontal lobe /cortex; functional magnetic resonance imaging; human subject; image processing; magnetic resonance imaging; memory; method development; neural information processing; neuroanatomy; neurosciences; stimulus /response; visual stimulus; young adult human (21-34)

DESCRIPTION (provided by applicant): A major issue in cognitive neuroscience is how specific neural pathways are organized for task performance. The major hypothesis of this proposal is that task-level control is implemented, in part, by activity sustained across task trials, and can be studied using fMRI. This hypothesis is addressed through 3 Specific Aims. Specific Aim 1: To refine paradigm designs and analysis methods for separating sustained and transient fMRI signals. The main hypothesis is that the mixed block/event related paradigm can be optimized for the accurate and sensitive identification of sustained "control" signals from transient "trial-related" fMRI signals. Specific Aim 2: To characterize the functional attributes of different regions exhibiting sustained activity across trials. Three general hypotheses will be tested: 1) Some regions will exhibit sustained activity across a wide range of tasks, implicating them in general control functions; 2) In spite of this commonality, manipulation of separable aspects of control (e.g., input or response selection) will differentially affect specific subsets of these regions; 3) Some regions will show sustained activity related to specific task domains, implicating them as sources of domain specific control, or as sites at which control signals affect ongoing trial-related processing. Specific Aim 3: To use properties of sustained signals to address issues specific to memory retrieval. Several episodic retrieval studies have shown activation of right frontal regions, and it has been proposed that this activity may be related to "retrieval mode". Two related hypotheses are tested: 1) Right frontal sustained activity will be found across conditions that demand "re-collective effort" or "re-collective mode"; 2) The right frontal sustained activity will not be specific to "recollection", but will also be present when complex retrieval constraints are placed at "intermediate levels" between recollection and familiarity. As a group, these studies should improve our understanding of task control processes in the brain. Several psychiatric and neurological diseases (e.g., Tourette's syndrome, frontal lobe strokes) have been related to deficits of control; a deeper understanding of the neural mechanisms related to control processes may allow more specific diagnostic, prognostic, or rehabilitative approaches to these difficulties than currently exist.

描述（由申请人提供）：认知神经科学的一个主要问题是如何组织特定的神经通路进行任务执行。这个建议的主要假设是，任务水平的控制是实现的，在一定程度上，通过活动持续跨任务试验，并可以使用功能磁共振成像研究。这一假设通过三个具体目标来解决。具体目标1：完善范式设计和分析方法，分离持续和瞬态fMRI信号。主要的假设是，混合块/事件相关的范式可以优化的持续的“控制”信号的准确和灵敏的识别从瞬态的“审判相关”的功能磁共振成像信号。具体目标2：表征在试验中表现出持续活性的不同区域的功能属性。三个一般假设将被测试：1）一些区域将在广泛的任务中表现出持续的活动，暗示它们在一般控制功能中; 2）尽管有这种共性，但对控制的可分离方面的操纵（例如，输入或反应选择）将不同地影响这些区域的特定子集; 3）一些区域将显示与特定任务域相关的持续活动，暗示它们是域特异性控制的来源，或者是控制信号影响正在进行的试验相关处理的位点。具体目标3：利用持续信号的特性来解决记忆检索特有的问题。一些情景提取的研究表明，激活的右额叶区域，并已提出，这种活动可能与“提取模式”。两个相关的假设进行了测试：1）右额叶持续活动将被发现的条件下，要求“重新集体的努力”或“重新集体模式”; 2）右额叶持续活动不会是特定的“回忆”，但也将存在复杂的检索约束时，被放置在“中间水平”之间的回忆和熟悉。作为一个群体，这些研究应该提高我们对大脑中任务控制过程的理解。几种精神和神经疾病（例如，抽动秽语综合征、额叶中风）与控制缺陷有关;对与控制过程相关的神经机制的更深入理解可能允许比目前存在的更具体的诊断、预后或康复方法来解决这些困难。

项目成果

Recent progress and outstanding issues in motion correction in resting state fMRI.

静止状态fMRI中的最新进展和运动校正问题。

• DOI: 10.1016/j.neuroimage.2014.10.044
• 发表时间: 2015-01-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Power JD;Schlaggar BL;Petersen SE
• 通讯作者: Petersen SE

Dissociating early and late error signals in perceptual recognition.

分离感知识别中的早期和晚期错误信号。

• DOI: 10.1162/jocn.2008.20155
• 发表时间: 2008
• 期刊: Journal of cognitive neuroscience
• 影响因子: 3.2
• 作者: Wheeler,MarkE;Petersen,StevenE;Nelson,StevenM;Ploran,ElisabethJ;Velanova,Katerina
• 通讯作者: Velanova,Katerina

Individual-specific features of brain systems identified with resting state functional correlations.

• DOI: 10.1016/j.neuroimage.2016.08.032
• 发表时间: 2017-02-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Gordon EM;Laumann TO;Adeyemo B;Gilmore AW;Nelson SM;Dosenbach NUF;Petersen SE
• 通讯作者: Petersen SE

The mixed block/event-related design.

• DOI: 10.1016/j.neuroimage.2011.09.084
• 发表时间: 2012-08-15
• 期刊: NEUROIMAGE
• 影响因子: 5.7
• 作者: Petersen, Steven E.;Dubis, Joseph W.
• 通讯作者: Dubis, Joseph W.

Brain Networks and Cognitive Architectures.

• DOI: 10.1016/j.neuron.2015.09.027
• 发表时间: 2015-10-07
• 期刊: Neuron
• 影响因子: 16.2
• 作者: Petersen SE;Sporns O
• 通讯作者: Sporns O