Neural-Electromagnetic-Hemodynamic Links in Humans

人类的神经-电磁-血流动力学联系

基本信息

  • 批准号:
    7048465
  • 负责人:
  • 金额:
    $ 33.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-04-01 至 2008-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The spatiotemporal dynamics of human brain activation can be non-invasively imaged by combining functional Magnetic Resonance Imaging (fMRI) with magneto- and electro-encephalography (M/EEG). fMRI locates altered cerebral hemodynamics with good spatial accuracy but poor temporal resolution. Conversely, M/EEG are instantaneous measures of population synaptic activity, but are hard to localize because of spatiotemporal cancellation. Furthermore, the transfer functions from cortical neuronal synaptic currents and cell-firing, to extracranial hemodynamic and electromagnetic signals, are unknown. The potential variability of the relationships of hemodynamic and electromagnetic signals to each other, and to their underlying neural substrates, make it necessary to explore and define these relations in behaving humans. We propose to measure neuronal activity using linear arrays of micro-electrodes. Optical measurements will quantify hemodynamics using cortical point spectroscopy and laser Doppler. Simultaneous measures within the same cortical micro-domain will be made during spontaneous activity, calibration states, and a variety of cognitive tasks. If successful, this research will reveal, at an unprecedented level of quantification and certainty, the relations between hemodynamic and electromagnetic measures, and the underlying activity of neuronal populations, during cognition in humans.
描述(由申请人提供):

项目成果

期刊论文数量(27)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The human K-complex represents an isolated cortical down-state.
  • DOI:
    10.1126/science.1169626
  • 发表时间:
    2009-05-22
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Cash SS;Halgren E;Dehghani N;Rossetti AO;Thesen T;Wang C;Devinsky O;Kuzniecky R;Doyle W;Madsen JR;Bromfield E;Eross L;Halász P;Karmos G;Csercsa R;Wittner L;Ulbert I
  • 通讯作者:
    Ulbert I
Experimental validation of the influence of white matter anisotropy on the intracranial EEG forward solution.
  • DOI:
    10.1007/s10827-009-0205-z
  • 发表时间:
    2010-12
  • 期刊:
  • 影响因子:
    1.2
  • 作者:
    Bangera NB;Schomer DL;Dehghani N;Ulbert I;Cash S;Papavasiliou S;Eisenberg SR;Dale AM;Halgren E
  • 通讯作者:
    Halgren E
The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients
  • DOI:
    10.1016/j.eplepsyres.2006.01.001
  • 发表时间:
    2006-04-01
  • 期刊:
  • 影响因子:
    2.2
  • 作者:
    Knake, S;Halgren, E;Stufflebeam, SM
  • 通讯作者:
    Stufflebeam, SM
In vivo laminar electrophysiology co-registered with histology in the hippocampus of patients with temporal lobe epilepsy.
颞叶癫痫患者海马体内层流电生理学与组织学共同记录。
  • DOI:
    10.1016/j.expneurol.2003.12.003
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    5.3
  • 作者:
    Ulbert,István;Maglóczky,Zsófia;Eross,Loránd;Czirják,Sándor;Vajda,János;Bognár,László;Tóth,Szabolcs;Szabó,Zerind;Halász,Péter;Fabó,Dániel;Halgren,Eric;Freund,TamásF;Karmos,George
  • 通讯作者:
    Karmos,George
Comparative power spectral analysis of simultaneous electroencephalographic and magnetoencephalographic recordings in humans suggests non-resistive extracellular media : EEG and MEG power spectra.
  • DOI:
    10.1007/s10827-010-0252-5
  • 发表时间:
    2010-06-17
  • 期刊:
  • 影响因子:
    1.2
  • 作者:
    Dehghani N;Bédard C;Cash SS;Halgren E;Destexhe A
  • 通讯作者:
    Destexhe A
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Eric Halgren其他文献

Eric Halgren的其他文献

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{{ truncateString('Eric Halgren', 18)}}的其他基金

CRCNS: Multiresolution Modeling of Human Thalamocortical Upstates and Downstates
CRCNS:人类丘脑皮质上部和下部的多分辨率建模
  • 批准号:
    8444924
  • 财政年份:
    2012
  • 资助金额:
    $ 33.21万
  • 项目类别:
CRCNS: Multiresolution Modeling of Human Thalamocortical Upstates and Downstates
CRCNS:人类丘脑皮质上部和下部的多分辨率建模
  • 批准号:
    8538511
  • 财政年份:
    2012
  • 资助金额:
    $ 33.21万
  • 项目类别:
CRCNS: Multiresolution Modeling of Human Thalamocortical Upstates and Downstates
CRCNS:人类丘脑皮质上部和下部的多分辨率建模
  • 批准号:
    9069516
  • 财政年份:
    2012
  • 资助金额:
    $ 33.21万
  • 项目类别:
CRCNS: Multiresolution Modeling of Human Thalamocortical Upstates and Downstates
CRCNS:人类丘脑皮质上部和下部的多分辨率建模
  • 批准号:
    8680375
  • 财政年份:
    2012
  • 资助金额:
    $ 33.21万
  • 项目类别:
Sequence and Location of Cortical Activity When Infants Understand Words
婴儿理解单词时皮层活动的顺序和位置
  • 批准号:
    8244439
  • 财政年份:
    2011
  • 资助金额:
    $ 33.21万
  • 项目类别:
Sequence and Location of Cortical Activity When Infants Understand Words
婴儿理解单词时皮层活动的顺序和位置
  • 批准号:
    8116717
  • 财政年份:
    2011
  • 资助金额:
    $ 33.21万
  • 项目类别:
Automated monitoring of MRI abnormalities in HIV/AIDS
自动监测 HIV/AIDS MRI 异常
  • 批准号:
    6841866
  • 财政年份:
    2004
  • 资助金额:
    $ 33.21万
  • 项目类别:
Automated monitoring of MRI abnormalities in HIV/AIDS
自动监测 HIV/AIDS MRI 异常
  • 批准号:
    6941315
  • 财政年份:
    2004
  • 资助金额:
    $ 33.21万
  • 项目类别:
Automated analysis of lesions and atrophy in MS
MS 病变和萎缩的自动分析
  • 批准号:
    6793527
  • 财政年份:
    2004
  • 资助金额:
    $ 33.21万
  • 项目类别:
Neural-Electromagnetic-Hemodynamic Links in Humans
人类的神经-电磁-血流动力学联系
  • 批准号:
    6870264
  • 财政年份:
    2003
  • 资助金额:
    $ 33.21万
  • 项目类别:

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