Automated monitoring of MRI abnormalities in HIV/AIDS

自动监测 HIV/AIDS MRI 异常

• 批准号: 6941315
• 负责人: Eric Halgren
• 金额: $ 30.68万
• 依托单位: CORTECHS LABS, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941315
• 关键词: AIDS; AIDS dementia complex; HIV infections; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain morphology; clinical research; computer assisted patient care; computer program /software; computer system design /evaluation; human data; image guided surgery /therapy; magnetic resonance imaging; neuropathology; neuropsychology; patient care management; patient oriented research

DESCRIPTION (provided by applicant): Neuropsychological problems are common in Human Immunodeficiency Virus infection (HIV) and Acquired Immune Deficiency Syndrome (AIDS), even in the absence of clearly visible cerebral lesions. In many cases, the origin of these problems in cerebral function is confounded by other issues, such as medication interactions, substance abuse, or emotional reaction to this devastating illness. Research using hand-delineation of cerebral structures suggests that specific neuropsychological problems are associated with decreased volume of the caudate nucleus. However, the expertise and time required to perform these manual measurements severely limit their application in clinical trials, and prevent them from being used in clinical practice. The overall goal of this project is to develop MRI-analysis software that can automatically and accurately quantify cerebral structures in patients with HIV/AIDS The outcome of this project will be commercialized as an HIV image-processing service for clinical trials and as medical device software providing HIV specific quantification. In a pharmacological research setting, the proposed software will allow non-invasive monitoring of cerebral status, thus providing objective criteria for developing treatment approaches to arrest or prevent AIDS dementia. In the clinical setting, the cerebral quantification provided by this software may eventually be applied to the selection of patients for treatment, and in the monitoring of treatments. Our first specific aim is to optimize our cerebral segmentation and quantification software for subjects with HIV/AIDS. Our second aim is to optimize our cortical labeling and quantification software for subjects with HIV/AIDS. Our third aim is to develop software quantifying tissue property changes in normal appearing white matter of subjects with HIV infection using Diffusion Tensor Imaging. Our fourth aim is to validate the automatic cerebral quantification software against "gold standard" manual segmentation methods in subjects infected with HIV. Fulfillment of these specific aims will demonstrate the feasibility and accuracy of automatic cerebral quantification software for HIV disease monitoring.

描述（由申请人提供）：神经心理问题在人类免疫缺陷病毒感染（HIV）和获得性免疫缺陷综合症（AIDS）中很常见，即使没有明显可见的脑损伤。在许多情况下，这些大脑功能问题的根源与其他问题相混淆，例如药物相互作用、药物滥用或对这种毁灭性疾病的情绪反应。使用手工描绘大脑结构的研究表明，特定的神经心理学问题与尾状核体积减少有关。然而，执行这些手动测量所需的专业知识和时间严重限制了它们在临床试验中的应用，并阻止它们在临床实践中使用。该项目的总体目标是开发 MRI 分析软件，能够自动、准确地量化 HIV/AIDS 患者的大脑结构。该项目的成果将作为用于临床试验的 HIV 图像处理服务和提供 HIV 特异性量化的医疗设备软件进行商业化。在药理学研究环境中，所提出的软件将允许对大脑状态进行非侵入性监测，从而为开发阻止或预防艾滋病痴呆的治疗方法提供客观标准。在临床环境中，该软件提供的脑部量化最终可能应用于选择接受治疗的患者以及监测治疗。我们的第一个具体目标是优化针对艾滋病毒/艾滋病患者的大脑分割和量化软件。我们的第二个目标是优化针对艾滋病毒/艾滋病受试者的皮质标记和定量软件。我们的第三个目标是开发软件，使用扩散张量成像来量化 HIV 感染者正常白质的组织特性变化。我们的第四个目标是在感染艾滋病毒的受试者中对照“黄金标准”手动分割方法验证自动脑定量软件。这些具体目标的实现将证明自动脑定量软件用于艾滋病毒疾病监测的可行性和准确性。