Center for experimental neurorehabilitation training

描述(由申请人提供)：减少神经残疾的进展越来越依赖于动物和人类关于神经可塑性和神经修复的研究的双向翻译。神经可塑性是指神经系统在解剖学或生理学上对外部或内部环境的扰动进行适应的能力，例如在中风或脊髓损伤后。神经修复指的是中断的轴突的再生和丢失的神经元的替换(或结合人工神经回路)。这两种类型的过程都可以在基因、神经元、代表思想和行动的神经元组件，以及编码运动、行为和认知的分布式神经系统的水平上进行检查。宾夕法尼亚大学和加州大学洛杉矶分校在拟建的实验神经康复训练中心(CENT)在神经科学、康复和功能成像方面拥有国际公认的互补优势。他们将合作，通过组织国家研讨会、校园研讨会、访问奖学金和基于网络的教学资源来促进神经康复的研究目标。PI和共同PI在促进基础研究、研究培训和教育项目方面有着长期的成功合作记录，以推动全球神经康复方面的进展。在他们的领导下，CENT将培训基础和临床研究人员使用尖端的生理学、解剖学和成像技术，包括在完整神经系统活细胞显微成像方面的最新创新，鼓励将其应用于神经可塑性和修复的研究，并将其转化为临床试验。教职员工将支持访问学者和其家乡机构的同事不断努力，以提高他们获得研究资金的能力。PI的教学计划将根据特定受众的需求，从概述到深入指导神经可塑性和修复的模型，从细胞到系统的整合。将资助试点研究，通过与其他中心的合作扩大这项工作的应用。执行委员会散发的信息将确保各国能够利用执行机构的专门知识和资源，执行委员会还将确定最合适的培训地点。这将极大地增强临床神经康复的科学基础和进展。

DESCRIPTION (provided by applicant): Progress in reducing neurological disabilities depends increasingly on bi-directional translation of animal and human studies on neuroplasticity and neural repair. Neuroplasticity refers to the ability of the nervous system to adapt anatomically or physiologically to perturbations of the external or internal environment, e.g., after stroke or spinal cord injury. Neural repair refers to regeneration of interrupted axons and replacement of lost neurons (or incorporation of prosthetic neural circuits). Both types of process can be examined at the level of genes, neurons, neuronal assemblies that represent thought and action, and distributed neural systems that encode movements, behaviors and cognition. The PENN and UCLA faculties in the proposed Center for Experimental Neurorehabilitation Training (CENT) have internationally recognized and complementary strengths in neuroscience, rehabilitation, and functional imaging. They will collaborate to further the research goals of neurorehabilitation by organizing national symposia, campus workshops, visiting fellowships, and web-based didactic resources. The PI and co-PI have a long track record of successful collaboration in promoting fundamental research, research training and educational programs to advance progress in neurorehabilitation worldwide. Under their leadership, CENT will train basic and clinical researchers in the use of cutting-edge physiological, anatomical, and imaging techniques, including recent innovations in microimaging of living cells in the intact nervous system, encouraging their application to studies of neuroplasticity and repair, and their translation into clinical trials. The faculty will support ongoing efforts of visiting fellows and colleagues at their home institutions to improve their ability to obtain research funds. The PIs' didactic programs will range from overviews to in-depth instruction in models of neuroplasticity and repair, integrated from cells to systems, depending on the needs of the specific audience. Pilot studies will be funded to expand the application of this work through collaboration with other centers. National access to the PIs' expertise and resources will be assured by information disseminated by the Executive Committee, which will also determine the most appropriate site for training. This will greatly enhance the scientific bases and progress of clinical neurorehabilitation.