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Center for experimental neurorehabilitation training

实验神经康复训练中心

基本信息

批准号：
8547941
负责人：
MICHAEL EDGAR SELZER
金额：
$ 18.9万
依托单位：
TEMPLE UNIV OF THE COMMONWEALTH
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-15 至 2013-07-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Progress in reducing neurological disabilities depends increasingly on bi-directional translation of animal and human studies on neuroplasticity and neural repair. Neuroplasticity refers to the ability of the nervous system to adapt anatomically or physiologically to perturbations of the external or internal environment, e.g., after stroke or spinal cord injury. Neural repair refers to regeneration of interrupted axons and replacement of lost neurons (or incorporation of prosthetic neural circuits). Both types of process can be examined at the level of genes, neurons, neuronal assemblies that represent thought and action, and distributed neural systems that encode movements, behaviors and cognition. The PENN and UCLA faculties in the proposed Center for Experimental Neurorehabilitation Training (CENT) have internationally recognized and complementary strengths in neuroscience, rehabilitation, and functional imaging. They will collaborate to further the research goals of neurorehabilitation by organizing national symposia, campus workshops, visiting fellowships, and web-based didactic resources. The PI and co-PI have a long track record of successful collaboration in promoting fundamental research, research training and educational programs to advance progress in neurorehabilitation worldwide. Under their leadership, CENT will train basic and clinical researchers in the use of cutting-edge physiological, anatomical, and imaging techniques, including recent innovations in microimaging of living cells in the intact nervous system, encouraging their application to studies of neuroplasticity and repair, and their translation into clinical trials. The faculty will support ongoing efforts of visiting fellows and colleagues at their home institutions to improve their ability to obtain research funds. The PIs' didactic programs will range from overviews to in-depth instruction in models of neuroplasticity and repair, integrated from cells to systems, depending on the needs of the specific audience. Pilot studies will be funded to expand the application of this work through collaboration with other centers. National access to the PIs' expertise and resources will be assured by information disseminated by the Executive Committee, which will also determine the most appropriate site for training. This will greatly enhance the scientific bases and progress of clinical neurorehabilitation.

描述（由申请人提供）：减少神经残疾的进展越来越依赖于动物和人类关于神经可塑性和神经修复研究的双向转化。神经可塑性是指神经系统在解剖学或生理学上适应外部或内部环境扰动的能力，例如中风或脊髓损伤后。神经修复是指中断的轴突的再生和丢失的神经元的替换（或假体神经回路的合并）。这两种类型的过程都可以在基因、神经元、代表思想和行动的神经元组件以及编码运动、行为和认知的分布式神经系统的水平上进行检查。拟建的实验神经康复训练中心 (CENT) 的宾夕法尼亚大学和加州大学洛杉矶分校的院系在神经科学、康复和功能成像方面拥有国际公认的互补优势。他们将通过组织全国研讨会、校园研讨会、访问奖学金和基于网络的教学资源来合作，进一步实现神经康复的研究目标。 PI 和 co-PI 在促进基础研究、研究培训和教育项目以推动全球神经康复方面的进展方面有着长期的成功合作记录。在他们的领导下，CENT 将培训基础和临床研究人员使用尖端的生理、解剖和成像技术，包括完整神经系统中活细胞显微成像的最新创新，鼓励其应用于神经可塑性和修复研究，并将其转化为临床试验。教师将支持访问学者和同事在其所在机构的持续努力，以提高他们获得研究经费的能力。 PI 的教学计划范围从神经可塑性和修复模型的概述到深入指导，从细胞到系统的整合，具体取决于特定受众的需求。将资助试点研究，通过与其他中心的合作扩大这项工作的应用。执行委员会传播的信息将确保国家获得 PI 的专业知识和资源，该委员会还将确定最合适的培训地点。这将极大增强临床神经康复的科学基础和进展。