Identifying new types of inhibitors in quinone binding sites in photosynthetic enzymes

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With the ever-rising global population, there is an increasing need for efficiency and sustainability in agriculture whilst preserving future food security. Enzymes with quinone binding sites play a key role as targets for agrochemicals, but the modes of inhibition are not well understood, and the discovery of new inhibitors occurs most and foremost through large-scale screening. In this project, we will investigate the mode of binding of quinone-site inhibitors using novel electron paramagnetic resonance (EPR) based approaches and use this knowledge to identify new inhibitors. Our target enzymes consist of both established targets (photosystem II) and a completely novel target (photosynthetic complex I / NDH).