Identifying new types of inhibitors in quinone binding sites in photosynthetic enzymes

鉴定光合酶醌结合位点的新型抑制剂

• 批准号: 2753921
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2753921
• 关键词: Identifying; new; types; inhibitors; quinone

With the ever-rising global population, there is an increasing need for efficiency and sustainability in agriculture whilst preserving future food security. Enzymes with quinone binding sites play a key role as targets for agrochemicals, but the modes of inhibition are not well understood, and the discovery of new inhibitors occurs most and foremost through large-scale screening. In this project, we will investigate the mode of binding of quinone-site inhibitors using novel electron paramagnetic resonance (EPR) based approaches and use this knowledge to identify new inhibitors. Our target enzymes consist of both established targets (photosystem II) and a completely novel target (photosynthetic complex I / NDH).

随着全球人口的不断增长，对农业效率和可持续性的需求日益增加，同时保持未来的粮食安全。具有醌结合位点的酶作为农用化学品的靶标发挥着关键作用，但抑制模式尚未得到很好的理解，新抑制剂的发现大多数和最重要的是通过大规模筛选。在这个项目中，我们将使用新的电子顺磁共振（EPR）为基础的方法，并利用这些知识来确定新的抑制剂的醌网站抑制剂的结合模式。我们的目标酶包括两个既定的目标（光系统II）和一个全新的目标（光合复合物I / NDH）。