Photoadapt: Light-switchable chameleonic molecules for controlled permeability in plants

Photoadapt：光控变色分子，用于控制植物的渗透性

• 批准号: 2754344
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2754344
• 关键词: Photoadapt; Light; switchable; chameleonic; molecules

Light is unsurpassed in its ability to control biological systems with high spatial and temporal resolution. It has the advantages of noninvasive and remote action, reversibility, speed, and facile modulation of the energies involved (through use of different wavelengths/colours). Photopharmacology is a growing area of endeavor that employs photoswitchable ligands of biological targets to allow for light-dependent pharmacological activity. The key component of such light addressable ligands are molecular 'photoswitches', such as azobenzene: components that can be interconverted between two different structural states, using light as the stimulus to drive at least one of the switching events. By integrating a photoswitch component into a biologically active ligand, light can be used to 'switch' the ligand between two states with different pharmacological activity: for example, switching target-based activity 'on' and 'off'. This project aims to use this emerging technology to address the issue of agrochemical permeability and transport in plants, and potentially lead to the development of multiple light-dependent approaches in plant chemical biology

光在控制生物系统方面具有无与伦比的能力，具有高空间和时间分辨率。它具有非侵入性和远程作用，可逆性，速度和所涉及的能量的容易调制（通过使用不同的波长/颜色）的优点。光药理学是一个不断奋进的领域，其采用生物靶标的光可切换配体以允许光依赖性药理活性。这种光可寻址配体的关键组分是分子“光开关”，例如偶氮苯：可以在两种不同结构状态之间相互转换的组分，使用光作为刺激来驱动至少一个开关事件。通过将光开关组分整合到生物活性配体中，光可用于在具有不同药理学活性的两种状态之间“切换"配体：例如，切换基于靶标的活性”开“和”关“。该项目旨在利用这一新兴技术来解决农业化学品在植物中的渗透和运输问题，并可能导致植物化学生物学中多种光依赖方法的发展