Including Active Transport in Cell Transport Phenomena

包括细胞运输现象中的主动运输

• 批准号: 6919094
• 负责人: Hernan Leonardo Martinez
• 金额: $ 19.15万
• 依托单位: CALIFORNIA STATE UNIV-DOMINGUEZ HILLS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6919094
• 关键词: active transport; biophysics; cell biology; computer simulation; kinesin; mathematical model; minority institution research support; passive transport

The ultimate purpose of our research is to understand the important metabolic processes taking place in the human cell. Our research at CSUDH has so far focused on the study of passive transport in in homogeneous media. We have developed an inovative approach based on a combination of mathematical techniques (renormalization, random walks, fluctuation-dissipation), new geometrical concepts (quasi-fractals), and computer simulations (Monte Carlo, Brownian dynamics) to study this topic. This work has now led us to study active transport. In this proposal, we intend to describe how cellular cargo diffuses through the viscous regions of the cell, how it is transported by molecular motors in the cytoskeleton, and how these types of transport are connected at the cellular level. Also, the cell is a dynamic structure and its inherent motion affects the transpot phenomena taking place inside. In order to integrate all these aspects, we will study the motion of particles while driven by thermal fluctuations on suitable dynamical and geometrical models of the cell. We will extend our general formalism to include active trasport and time distributions to represent the random nature and dynamics of the cell.

我们研究的最终目的是了解人体细胞中发生的重要代谢过程。迄今为止，我们在 CSUDH 的研究主要集中在均质介质中的被动传输研究。我们开发了一种基于数学技术（重正化、随机游走、波动耗散）、新几何概念（准分形）和计算机模拟（蒙特卡罗、布朗动力学）相结合的创新方法来研究这一主题。这项工作现在引导我们研究主动运输。在本提案中，我们打算描述细胞货物如何通过细胞的粘性区域扩散，如何通过细胞骨架中的分子马达运输，以及这些类型的 运输在细胞水平上连接。此外，细胞是一个动态结构，其固有运动会影响内部发生的转运现象。为了整合所有这些方面，我们将在适当的细胞动力学和几何模型上研究由热波动驱动的粒子的运动。我们将扩展我们的一般形式主义，以包括主动运输和时间分布，以表示细胞的随机性质和动态。