Including Active Transport in Cell Transport Phenomena

包括细胞运输现象中的主动运输

• 批准号: 6919094
• 负责人: Hernan Leonardo Martinez
• 金额: $ 19.15万
• 依托单位: CALIFORNIA STATE UNIV-DOMINGUEZ HILLS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6919094
• 关键词: active transport; biophysics; cell biology; computer simulation; kinesin; mathematical model; minority institution research support; passive transport

The ultimate purpose of our research is to understand the important metabolic processes taking place in the human cell. Our research at CSUDH has so far focused on the study of passive transport in in homogeneous media. We have developed an inovative approach based on a combination of mathematical techniques (renormalization, random walks, fluctuation-dissipation), new geometrical concepts (quasi-fractals), and computer simulations (Monte Carlo, Brownian dynamics) to study this topic. This work has now led us to study active transport. In this proposal, we intend to describe how cellular cargo diffuses through the viscous regions of the cell, how it is transported by molecular motors in the cytoskeleton, and how these types of transport are connected at the cellular level. Also, the cell is a dynamic structure and its inherent motion affects the transpot phenomena taking place inside. In order to integrate all these aspects, we will study the motion of particles while driven by thermal fluctuations on suitable dynamical and geometrical models of the cell. We will extend our general formalism to include active trasport and time distributions to represent the random nature and dynamics of the cell.

我们研究的最终目的是了解人类细胞中发生的重要代谢过程。到目前为止，我们在CSUDH的研究集中在同质媒体中的被动运输研究上。我们已经建立了一种基于数学技术（重新归一化，随机步行，波动散落），新的几何概念（准屈服）和计算机模拟（蒙特卡洛，布朗，布朗动力学）的组合，开发了一种不可行的方法。这项工作现在使我们研究了积极的运输。在此提案中，我们打算描述细胞货物如何通过细胞的粘性区域扩散，如何通过细胞骨架中的分子电动机传输。 转运在细胞水平上连接。同样，细胞是一个动态结构，其固有的运动会影响内部发生的转换现象。为了整合所有这些方面，我们将研究颗粒的运动，同时由细胞的适当动力学和几何模型的热波动驱动。我们将扩展一般形式主义，以包括主动的trasport和时间分布，以表示细胞的随机性质和动力学。