CCD detector

CCD探测器

• 批准号: 6876881
• 负责人: Carol Muehleman
• 金额: $ 10.17万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6876881
• 关键词: articular cartilage; bioimaging /biomedical imaging; biomedical equipment purchase; charge coupled device camera; digital imaging; musculoskeletal imaging /visualization /scanning; noninvasive diagnosis; osteoarthritis

DESCRIPTION (provided by applicant): The assessment of the degree of cartilage degeneration in degenerative joint disease can only be carried out through the invasive technique of arthroscopy, or to a limited extent through Magnetic Resonance Imaging. Although particular cartilage is invisible with conventional radiography, we have previously shown that a novel radiography technique called Diffraction Enhanced X-ray Imaging (DEI) allows the visualization of cartilage and other soft tissues. The goal of this project is to increase the resolution and efficiency of the DEI set-up at the National Synchrotron Light Source of Brookhaven National Laboratory by the replacement of its current image detector in order to increase imaging quality. Currently, there are several medically-oriented X-ray imaging projects underway at the facility, including an NIH Bioengineering Research Partnership dedicated to the imaging of the particular cartilage disease. A new, higher resolution detector will be purchased and installed so as to attain the best possible images for diagnosis of pathology and the determination of the capabilities of the DEI technique under optimal technological conditions. Since the laboratory is already a multi-user facility, the addition of a higher resolution detector will allow each of the present users to attain data of higher quality and with greater information than is currently attainable at the present site. Furthermore, optimization of the technique will facilitate its use by other investigators requiring an imaging resolution high enough for cartilage substructure and small animal joints. DEI technology is now being adopted as a research tool around the world. Thus, with growing competition at European, Asian, and Canadian DEI imaging sites that are already equipped with higher resolution detectors than that at the NSLS facility, the NSLS users are both at a competitive disadvantage as well as incapable of producing the highest quality images that are technologically feasible. Additionally, the optimized facility will greatly enhance the productivity of each user group as a consequence of detector efficiency.

描述(由申请人提供)： 退行性关节疾病软骨退变程度的评估只能通过侵入性的关节镜技术进行，或在一定程度上通过磁共振成像进行。虽然特定的软骨是不可见的，但我们之前已经证明，一种名为衍射增强X射线成像(DEI)的新放射成像技术可以显示软骨和其他软组织。该项目的目标是通过更换现有的图像探测器来提高布鲁克海文国家实验室国家同步加速器光源的DEI设置的分辨率和效率，以提高成像质量。目前，该设施正在进行几个以医学为导向的X射线成像项目，其中包括致力于对特定软骨疾病进行成像的NIH生物工程研究伙伴关系。将购买和安装一台新的、更高分辨率的探测器，以便获得尽可能好的图像，用于病理诊断和在最佳技术条件下确定DEI技术的能力。由于该实验室已经是一个多用户设施，增加一个更高分辨率的探测器将使目前的每个用户都能获得比目前在本地点可获得的更高质量和更多信息的数据。此外，该技术的优化将有助于其他研究人员使用该技术，这些研究人员需要足够高的成像分辨率来研究软骨亚结构和小动物关节。DEI技术现在正被世界各地作为一种研究工具采用。因此，随着欧洲、亚洲和加拿大DEI成像站点的竞争日益激烈，这些站点已经配备了比NSLS设施更高的分辨率探测器，NSLS用户既处于竞争劣势，又无法产生技术上可行的最高质量的图像。此外，优化的设施将大大提高每个用户组的生产力，这是探测器效率的结果。