CCD detector

CCD探测器

• 批准号: 6876881
• 负责人: Carol Muehleman
• 金额: $ 10.17万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6876881
• 关键词: articular cartilage; bioimaging /biomedical imaging; biomedical equipment purchase; charge coupled device camera; digital imaging; musculoskeletal imaging /visualization /scanning; noninvasive diagnosis; osteoarthritis

DESCRIPTION (provided by applicant): The assessment of the degree of cartilage degeneration in degenerative joint disease can only be carried out through the invasive technique of arthroscopy, or to a limited extent through Magnetic Resonance Imaging. Although particular cartilage is invisible with conventional radiography, we have previously shown that a novel radiography technique called Diffraction Enhanced X-ray Imaging (DEI) allows the visualization of cartilage and other soft tissues. The goal of this project is to increase the resolution and efficiency of the DEI set-up at the National Synchrotron Light Source of Brookhaven National Laboratory by the replacement of its current image detector in order to increase imaging quality. Currently, there are several medically-oriented X-ray imaging projects underway at the facility, including an NIH Bioengineering Research Partnership dedicated to the imaging of the particular cartilage disease. A new, higher resolution detector will be purchased and installed so as to attain the best possible images for diagnosis of pathology and the determination of the capabilities of the DEI technique under optimal technological conditions. Since the laboratory is already a multi-user facility, the addition of a higher resolution detector will allow each of the present users to attain data of higher quality and with greater information than is currently attainable at the present site. Furthermore, optimization of the technique will facilitate its use by other investigators requiring an imaging resolution high enough for cartilage substructure and small animal joints. DEI technology is now being adopted as a research tool around the world. Thus, with growing competition at European, Asian, and Canadian DEI imaging sites that are already equipped with higher resolution detectors than that at the NSLS facility, the NSLS users are both at a competitive disadvantage as well as incapable of producing the highest quality images that are technologically feasible. Additionally, the optimized facility will greatly enhance the productivity of each user group as a consequence of detector efficiency.

描述（由申请人提供）： 退行性关节疾病中软骨退变程度的评估只能通过关节镜的侵入性技术进行，或在有限程度上通过磁共振成像进行。虽然特定的软骨是不可见的与传统的放射线摄影，我们以前已经表明，一种新的放射线摄影技术称为衍射增强X射线成像（DEI）允许软骨和其他软组织的可视化。该项目的目标是通过更换布鲁克海文国家实验室国家同步加速器光源的现有图像探测器来提高DEI装置的分辨率和效率，以提高成像质量。目前，该设施正在进行几个面向医学的X射线成像项目，包括致力于特定软骨疾病成像的NIH生物工程研究伙伴关系。将购买和安装一个新的、分辨率更高的探测器，以便获得尽可能好的图像，用于病理诊断和确定DEI技术在最佳技术条件下的能力。由于该实验室已经是一个多用户设施，增加一个更高分辨率的探测器将使目前的每一个用户都能获得比目前在该地点所能获得的更高质量和更多信息的数据。此外，该技术的优化将促进其使用的其他研究人员需要一个成像分辨率足够高的软骨子结构和小动物关节。DEI技术现在被世界各地采用为研究工具。因此，随着欧洲、亚洲和加拿大DEI成像站点的竞争日益激烈，这些站点已经配备了比NSLS设施更高分辨率的探测器，NSLS用户既处于竞争劣势，也无法产生技术上可行的最高质量图像。此外，由于探测器的效率，优化后的设施将大大提高每个用户组的生产率。