NOVEL X-RAY TECHNOLOGY FOR DEGENERATIVE JOINT DISEASE

用于治疗退行性关节疾病的新型 X 射线技术

• 批准号: 7084583
• 负责人: Carol Muehleman
• 金额: $ 63.05万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7084583
• 关键词: X ray; ankle; articular cartilage; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biophysics; computer graphics /printing; diagnosis design /evaluation; early diagnosis; histology; human tissue; image enhancement; knee; laboratory rabbit; magnetic resonance imaging; mathematical model; musculoskeletal disorder diagnosis; neoplasm /cancer diagnosis; osteoarthritis; radiography; synchrotrons

We propose a program to integrate biomedical (Rush Medical College) with bioengineering (Illinois Institute of Technology and Massachusetts Institute of Technology) approaches to test and refine a novel X-ray technology for the diagnosis of joint pathology, particularly osteoarthritis. This technology may aid in the development of disease modifying agents and treatment strategies for the prevention and treatment of joint diseases. This project utilizes a novel synchrotron x-ray technique called diffraction enhanced imaging (DEI) which derives dramatic gains in contrast over conventional radiographs by exploiting x-ray refraction and scatter rejection (extinction) in addition to the usual absorption of conventional radiography. This technique, originally developed for mammary carcinoma imaging analyzes soft tissue as high contrast images with very high (greater than 0.05mm) spatial resolution. Although the synchrotron is currently used for DE imaging, the technique is not, in principle, tied to it. We have already shown that DEI is capable of imaging normal and degenerated articular cartilage of synovial joints showing features unique to this type of imaging using exposure times comparable to those of ordinary radiography. Beginning in the first year, we will interpret the cartilage and bone data obtained through our DEI methodologies by using the biological profiles of the matrix components as garnered through morphologic, biochemical and biophysical analysis. Some of the features observed in the DE images are not immediately explainable in molecular, chemical or structural terms. By using a unique integrated experimental approach, correlating biochemical and morphological tissue profiles with DE images, we hope to refine the overall DEI system for the detection of joint disease and, potentially, for other pathologies. We will image human and animal synovial joints and begin the refinement of the imaging technique for the optimal identification of early cartilage lesions. Animal models of cartilage degeneration will be used particularly for DE imaging of cartilage prior to visible signs of degeneration. Beginning in year two, we will image human cartilage that has been biomechanically damaged under controlled conditions for observation through DE imaging. We will also begin developing new DEI methodologies to produce images conveying more comprehensive information about the properties of the cartilage tissue, first for planar and then for 3D computed tomography. Throughout years one through five of the proposed project, there will be an iterative process of comparing biological analytical data with imaging data for the refinement of the DEI technique for joint tissues. Our long-term goal is to identify and localize initial phases of cartilage degeneration and follow their progression with the ultimate aim of monitoring disease progression and therapeutic interventions.

我们提出了一项计划，将生物医学(拉什医学院)与生物工程(伊利诺伊理工学院和麻省理工学院)的方法相结合，以测试和改进一种用于关节病理诊断的新型X射线技术，特别是骨关节炎。这项技术可能有助于开发疾病改良剂和治疗策略，以预防和治疗关节疾病。该项目利用了一种名为衍射增强成像(DEI)的新型同步加速器x射线技术，该技术除了利用传统射线照相的通常吸收外，还利用了x射线折射和散射抑制(消光)，从而获得了与传统射线照相相比显著的对比度增益。这项技术最初是为乳腺癌成像开发的，它将软组织分析为具有非常高(大于0.05 mm)空间分辨率的高对比度图像。虽然同步加速器目前用于DE成像，但原则上这项技术并不与之捆绑在一起。我们已经证明，DEI能够成像滑膜关节的正常和退变的关节软骨，显示出这种成像所特有的特征，使用与普通X光片相当的曝光时间。从第一年开始，我们将使用通过形态、生化和生物物理分析获得的基质成分的生物学特征来解释通过DEI方法获得的软骨和骨骼数据。DE图像中观察到的一些特征不能立即用分子、化学或结构术语解释。通过使用一种独特的综合实验方法，将生化和形态组织特征与DE图像相关联，我们希望完善整个DEI系统，用于检测关节疾病，并潜在地用于其他病理。我们将对人类和动物的滑膜关节进行成像，并开始改进成像技术，以最佳地识别早期软骨损伤。软骨退变的动物模型将特别用于在可见的退变迹象之前对软骨进行DE成像。从第二年开始，我们将通过DE成像对在受控条件下生物力学损伤的人类软骨进行成像观察。我们还将开始开发新的DEI方法，以产生传达关于软骨组织属性的更全面信息的图像，首先是平面图像，然后是3D计算机断层扫描。在拟议项目的第一年到第五年中，将有一个迭代过程，将生物分析数据与成像数据进行比较，以完善关节组织的DEI技术。我们的长期目标是识别和定位软骨退变的初始阶段，并跟踪其进展，最终目的是监测疾病进展和治疗干预。

项目成果

Mass density images from the diffraction enhanced imaging technique.

来自衍射增强成像技术的质量密度图像。

• DOI: 10.1118/1.1852794
• 发表时间: 2005
• 期刊: Medical physics
• 影响因子: 3.8
• 作者: Hasnah,MO;Parham,C;Pisano,ED;Zhong,Z;Oltulu,O;Chapman,D
• 通讯作者: Chapman,D

Analyzer-based imaging of spinal fusion in an animal model.

动物模型中基于分析仪的脊柱融合成像。

• DOI: 10.1088/0031-9155/53/10/011
• 发表时间: 2008
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Kelly,ME;Beavis,RC;Fiorella,David;Schultke,E;Allen,LA;Juurlink,BH;Zhong,Z;Chapman,LD
• 通讯作者: Chapman,LD

Characterization of diffraction-enhanced imaging contrast in breast cancer.

乳腺癌衍射增强成像对比度的表征。

• DOI: 10.1088/0031-9155/54/10/019
• 发表时间: 2009
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Kao,T;Connor,D;Dilmanian,FA;Faulconer,L;Liu,T;Parham,C;Pisano,ED;Zhong,Z
• 通讯作者: Zhong,Z

Qualitative evaluation of titanium implant integration into bone by diffraction enhanced imaging.

通过衍射增强成像对钛植入物与骨的整合进行定性评估。

• DOI: 10.1088/0031-9155/51/5/019
• 发表时间: 2006
• 期刊: Physics in medicine and biology
• 影响因子: 3.5
• 作者: Wagner,A;Sachse,A;Keller,M;Aurich,M;Wetzel,W-D;Hortschansky,P;Schmuck,K;Lohmann,M;Reime,B;Metge,J;Arfelli,F;Menk,R;Rigon,L;Muehleman,C;Bravin,A;Coan,P;Mollenhauer,J
• 通讯作者: Mollenhauer,J

Computed tomography of amyloid plaques in a mouse model of Alzheimer's disease using diffraction enhanced imaging.

• DOI: 10.1016/j.neuroimage.2009.03.019
• 发表时间: 2009-07-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Connor DM;Benveniste H;Dilmanian FA;Kritzer MF;Miller LM;Zhong Z
• 通讯作者: Zhong Z