Shared Instrument: Focus microPET

描述（由申请人提供）： 市售Focus是一种专用的超高分辨率小动物3D正电子发射断层扫描仪（PET）（Concorde Microsystems），采用正硅酸镥（LSO）探测器模块。Focus中的LSO块的独特之处在于相邻晶体元件之间的间距（约1x 1 mm）明显窄于其他系统，从而显著提高了空间分辨率约-1 mm（体积分辨率：1 mm 3-比当前一代microPET好10倍）。我们有3年使用Concorde旧设计R4 microPET的经验-共发表了23篇论文和25篇摘要。尽管非常有用，但R4在小鼠肿瘤模型（异种移植、转基因和敲除）中的定量具有严重的局限性。因此，我们的microPET用户将大大受益于Focus提供的最先进的功能-除了为我们许多涉及放射性示踪剂成像的资助研究提供急需的额外microPET成像时间。我们相信，凭借我们的经验和专业知识，我们非常适合充分利用Focus的能力。此外，一个完善的基础设施已经到位，以提供和协调必要的后勤，技术和科学组成部分，成功的小动物成像计划至关重要。例如，回旋加速器和放射化学核心实验室包括我们新的（但已全面投入使用）双束19/9 Ebco回旋加速器，产生大量正电子放射性核素（如碳-11、氟-18、镓-66、钇-86、碘-124等）和放射性示踪剂（例如C11-秋水仙碱和-甲硫氨酸、F18-FMiso、-FEAU和-FDHT、Ga66-DOTATOC、Y86-DOTA-生物素和I124-FIAU和IAZG）。使用这样的多个放射性示踪剂，区域肿瘤灌注，代谢，受体和抗原水平，缺氧和基因表达可以通过microPET在同一动物中连续评估-在治疗之前，期间和之后，包括MSKCC正在开发的许多新的药物，放射和放射性核素疗法。总之，MSKCC的动物成像核心设施正在被越来越多的受资助研究人员使用，分子成像已成为我们研究设备的关键组成部分。收购最先进的Focus将是对现有资源的宝贵补充，并将进一步增强我们中心范围内的分子成像关键任务能力。

DESCRIPTION (provided by applicant): The commercially available Focus is a dedicated ultra-high-resolution small-animal 3D positron emission tomograph (PET) (Concorde Microsystems) employing lutetium ortho-oxysilicate (LSO) detector blocks. The LSO blocks in the Focus are unique in that the spacing between adjacent crystal elements (approximately 1x1 mm) is significantly narrower than in other systems, yielding significantly improved spatial resolution approximately- 1 mm (volume resolution: 1 mm3 - 10-fold better than current-generation microPETs). We have had 3 years experience with Concorde's older-design R4 microPET -resulting in 23 publications and 25 abstracts. Although very useful, the R4 has serious limitations for quantification in mouse tumor models (xenograft, transgenic, and knock-out). Our microPET users will thus greatly benefit from the state-of-the-art capabilities offered by the Focus - besides providing badly needed additional microPET imaging time for our many funded studies that involve imaging of radiotracers. We believe that we are well suited by experience and expertise to fully exploit the capabilities of the Focus. In addition, a well-established infrastructure is already in place to provide and coordinate the necessary logistical, technical, and scientific components critical to a successful small-animal imaging program. For example, the Cyclotron and Radiochemistry Core Laboratory includes our new (but fully operational) dual-beam, 19/9 Ebco cyclotron, producing a broad array of positron-emitting radionuclides (eg carbon-11, fluorine-18, gallium-66, yttium-86, iodine-124 etc) and radiotracers (e.g. C11-colchicine and -methionine, F18-FMiso, -FEAU, and -FDHT, Ga66-DOTATOC, Y86-DOTA-Biotin, and I124-FIAU and IAZG). Using such multiple radiotracers, regional tumor perfusion, metabolism, receptor and antigen levels, hypoxia, and gene expression can be assessed serially by microPET in the same animal - prior to, during, and after treatment, including the many novel drug, radiation, and radionuclide therapies being developed at MSKCC. In summary, the Animal Imaging Core Facility at MSKCC is being utilized by a continually expanding number of funded investigators and molecular imaging has emerged as a critical component of our research armamentarium. Acquisition of the state-of-the-art Focus will be an invaluable adjunct to resources already in place, and will further enhance our Center-wide, mission-critical capabilities in molecular imaging.