Imaging Core
成像核心
基本信息
- 批准号:7438489
- 负责人:
- 金额:$ 32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-06-05 至 2013-04-30
- 项目状态:已结题
- 来源:
- 关键词:AnimalsAutoradiographyBiological AssayBioluminescenceCell ProliferationDevelopmentFire - disastersFluorescenceGeneticGlycolysisHeat-Shock Proteins 70HumanHypoxiaHypoxia Inducible FactorImageImaging TechniquesImaging technologyIndividualInvasiveLongitudinal StudiesMemorial Sloan-Kettering Cancer CenterMetabolicModalityMonitorNumbersOpticsPatientsPositron-Emission TomographyRadioisotopesRadionuclide ImagingReporterReporter GenesResearch Project GrantsResponse ElementsSystemTP53 geneTechniquesTranslatingbasein vivomalignant breast neoplasmmolecular imagingmouse modelneoplastic cellnon-invasive systemsingle photon emission computed tomographytraffickingtumor
项目摘要
The theme of the Imaging Core is molecular imaging of mouse models of human breast cancer.
The Core provides individual projects with non-invasive, quantitative imaging-based capabilities for
metabolic and genetic characterization of tumors and their microenvironment, including in vivo
trafficking of tumor cells. This will be accomplished by monitoring of "directly-targeting" probes and of
the expression of single and multi-modality reporter genes using optical (bioluminescence and
fluorescence), radionuclide (PET, SPECT, and autoradiography), MRI/MRS, CT, and US) imaging.
These quantitative, non-invasive imaging techniques are well-established at MSKCC for both smallanimal
and patient imaging studies. They are quantitative and non-invasive and thus readily adaptable to
longitudinal studies. The Imaging Core can readily provide [18F]-FDG, [18F]-FLT, [18F]-ACBC , and
[I8F]-FMISO or [124I]-IAZG microPET to all RPs for non-invasive assessment of tumor glycolysis, cell
proliferation, amino transport, and hypoxia, respectively, in mouse models of breast cancer. Further, a
number of inducible reporter systems for non-invasive in vivo imaging in small animals have been
developed. These reporter systems are all multi-modality reporters and include the capability for
fluorescence, bioluminescence and radionuclide imaging. In addition to p53 and DFHR, the list of
inducible reporters includes NFAT, FIRE (hypoxia response element - hypoxia inducible factor), E2F,
Forkhead factor (FOXO), heat shock protein 70 (HSP70) and TGFp. A general two-step strategy is
generally pursued in probe development: first, to establish and validate imaging and non-invasive assay
techniques in experimental animals, and second, to translate where appropriate selected aspects of our
imaging technology to patient studies within the context of the Research Projects (RPs) proposed in this
Application. The Imaging Core will actively and directly support all five RPs, led by Harold Varmus,
Joan Massague, Neil Rosen, Maria Jasin, and Robert Benezra, respectively.
成像核心的主题是人类乳腺癌小鼠模型的分子成像。
Core为各个项目提供了基于非侵入性定量成像的功能,
肿瘤及其微环境的代谢和遗传特征,包括体内
肿瘤细胞的运输。这将通过监测“直接靶向”探针和
使用光学(生物发光和生物荧光)的单模态和多模态报告基因的表达
放射性核素(PET、SPECT和放射自显影)、MRI/MRS、CT和US)成像。
这些定量、非侵入性成像技术在MSKCC已为小动物和
和患者成像研究。它们是定量和非侵入性的,因此易于适应
纵向研究。成像核心可以容易地提供[18F]-FDG、[18F]-FLT、[18F]-ACBC和[18F]-FDG。
对所有RP进行[I8 F]-FMISO或[124 I]-IAZG microPET,用于肿瘤糖酵解、细胞
增殖、氨基转运和缺氧。此外,A
用于小动物体内非侵入性成像的许多诱导型报告系统已经
开发这些报告器系统都是多模态报告器,并且包括以下功能:
荧光、生物发光和放射性核素成像。除了p53和DFHR之外,还有
诱导型报告基因包括NFAT,FIRE(缺氧反应元件-缺氧诱导因子),E2 F,
叉头因子(FOXO)、热休克蛋白70(HSP 70)和TGF β。一般的两步战略是
通常在探针开发中追求:首先,建立和验证成像和非侵入性测定
第二,在适当的情况下,翻译我们的选择方面,
在本研究中提出的研究项目(RP)的背景下,
应用程序.成像核心将积极和直接支持所有五个RP,由哈罗德瓦姆斯领导,
琼·马萨格,尼尔罗森,玛丽亚·贾辛和罗伯特·贝内兹拉。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Steven Mark Larson其他文献
PET/MRI for neuroendocrine tumors: a match made in heaven or just another hype?
- DOI:
10.1007/s40336-019-00344-1 - 发表时间:
2019-09-20 - 期刊:
- 影响因子:1.600
- 作者:
Ali Pirasteh;Christopher Riedl;Marius Erik Mayerhoefer;Romina Grazia Giancipoli;Steven Mark Larson;Lisa Bodei - 通讯作者:
Lisa Bodei
Steven Mark Larson的其他文献
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{{ truncateString('Steven Mark Larson', 18)}}的其他基金
124I-cG250 ImmunoPET Imaging of Sunitinib Treatment Response in Renal Cell Cancer
肾细胞癌舒尼替尼治疗反应的 124I-cG250 免疫 PET 成像
- 批准号:
8338883 - 财政年份:2011
- 资助金额:
$ 32万 - 项目类别:
124I-cG250 ImmunoPET Imaging of Sunitinib Treatment Response in Renal Cell Cancer
肾细胞癌舒尼替尼治疗反应的 124I-cG250 免疫 PET 成像
- 批准号:
8257032 - 财政年份:2011
- 资助金额:
$ 32万 - 项目类别:
Molecular Imaging of Castrate- Resistance Metastatic Prostate Cancer
去势抵抗性转移性前列腺癌的分子影像
- 批准号:
7729472 - 财政年份:2008
- 资助金额:
$ 32万 - 项目类别:
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