Data Coordinating Center for Autism & Other Disabilities

说明(改编自申请人S摘要)：自闭症是一种复杂的行为障碍，表现在婴幼儿或儿童早期，尽管其起源可能是遗传的或产前的。其临床表现的特点是社交和沟通障碍，以及重复的、刻板的行为。疾病控制和预防中心(CDC)/国家出生缺陷和发育障碍中心向各州或其指定实体授予了一系列多年合作协议，以建立自闭症监测项目、自闭症和发育障碍研究以及流行病学CADDRE。目前有6个资助的CADDRE网站和7个资助的ADDM网站。与CDC的这项合作协议的目的是让密歇根州立大学数据协调中心(MSU-DCC)作为一项多中心研究的数据协调中心，以支持与发展障碍相关的监测数据和研究数据管理，如自闭症谱系障碍(ASD)和其他发展障碍(DD)。MSU-DCC将与放射工程集团(REG)合作，协调和促进ADDM和CADDRE受权站点的数据管理活动。MSU-DCC将在该项目的协调中发挥主导作用，并将负责中央数据收集、质量控制、管理、设计和数据统计分析。REG将在开发基于网络的数据收集系统方面提供技术援助，并在各个地点提供培训。在该项目的第一阶段，将与疾控中心工作人员协商，制定一项简明、连贯的行动计划。流行病学系将提供有关方法和分析问题的专门知识。来自密歇根州社区卫生部门、三角研究所和北卡罗来纳大学教堂山分校的几名顾问已同意就该项目的各个方面提供他们的专业知识。

DESCRIPTION (adapted from Applicant(s abstract): Autism is a complex behavioral disorder manifesting in infancy or early childhood, although its origin may be genetic or prenatal. Its clinical presentation is characterized by impairments in social interaction and communication, and by repetitive, stereotyped behaviors. The Centers for Disease Control and Prevention (CDC) / National Center on Birth Defects and Developmental Disabilities have awarded a series of multi-year cooperative agreements to states or their designated entities to establish autism surveillance programs, Autism and Developmental Disabilities Research and Epidemiology CADDRE. Currently there are 6 funded CADDRE sites and 7 funded ADDM sites. The purpose of this cooperative agreement, with CDC, is for the Michigan State University Data Coordinating Center (MSU-DCC) to serve as a data coordinating center for a multicenter study to support surveillance data and research data management related developmental disabilities, such as Autism Spectrum Disorders (ASD) and other Developmental Disabilities (DD). The MSU-DCC in partnership with the Radiology Engineering Group (REG) will cooridinate and facilitate data mangement activities across both ADDM and CADDRE grantee sites. MSU-DCC will take the lead role in cooridination of this project and will be responsible for central data collection, quality control, management, design and statistical analysis of the data. The REG will provide technical assistance in developing web-based data collection systems and provide training at various sites. During the first phase of this project a concise and coherent plan of action will be developed in consultation with the CDC staff. The Department of Epidemiology will provide expertise relevant to the methodological and analytical issues. Several consultants from Michigan Department of Community Health, Research Triangle Institute, and the University of North Carolina -Chapel Hill have agreed to to provide their expertise on various aspects of this project.