Data Coordinating Center for Autism & Other Disabilities

描述（改编自申请人摘要）：自闭症是一种复杂的行为障碍，表现在婴儿期或幼儿期，尽管其起源可能是遗传的或产前的。其临床表现的特点是社会交往和沟通障碍，以及重复的刻板行为。美国疾病控制和预防中心/国家出生缺陷和发育残疾中心已与各州或其指定的实体签订了一系列多年合作协议，以建立自闭症监测项目、自闭症和发育残疾研究和流行病学（CADDRE）。目前有6个资助的CADDRE站点和7个资助的ADDM站点。这份与CDC合作协议的目的是让密歇根州立大学数据协调中心（MSU-DCC）作为多中心研究的数据协调中心，以支持与发育性残疾（如自闭症谱系障碍（ASD）和其他发育性残疾（DD））相关的监测数据和研究数据管理。MSU-DCC与放射工程小组（REG）合作，将协调和促进ADDM和CADDRE受资助站点的数据管理活动。MSU-DCC将在该项目的协调中发挥主导作用，并将负责中央数据收集、质量控制、管理、设计和数据统计分析。研究小组将为开发基于网络的数据收集系统提供技术援助，并在不同地点提供培训。在该项目的第一阶段，将与疾病预防控制中心工作人员协商制定一项简明而连贯的行动计划。流行病学司将提供与方法和分析问题有关的专门知识。来自密歇根社区卫生系、三角研究所和北卡罗来纳大学教堂山分校的几位顾问已同意就该项目的各个方面提供他们的专业知识。

DESCRIPTION (adapted from Applicant(s abstract): Autism is a complex behavioral disorder manifesting in infancy or early childhood, although its origin may be genetic or prenatal. Its clinical presentation is characterized by impairments in social interaction and communication, and by repetitive, stereotyped behaviors. The Centers for Disease Control and Prevention (CDC) / National Center on Birth Defects and Developmental Disabilities have awarded a series of multi-year cooperative agreements to states or their designated entities to establish autism surveillance programs, Autism and Developmental Disabilities Research and Epidemiology CADDRE. Currently there are 6 funded CADDRE sites and 7 funded ADDM sites. The purpose of this cooperative agreement, with CDC, is for the Michigan State University Data Coordinating Center (MSU-DCC) to serve as a data coordinating center for a multicenter study to support surveillance data and research data management related developmental disabilities, such as Autism Spectrum Disorders (ASD) and other Developmental Disabilities (DD). The MSU-DCC in partnership with the Radiology Engineering Group (REG) will cooridinate and facilitate data mangement activities across both ADDM and CADDRE grantee sites. MSU-DCC will take the lead role in cooridination of this project and will be responsible for central data collection, quality control, management, design and statistical analysis of the data. The REG will provide technical assistance in developing web-based data collection systems and provide training at various sites. During the first phase of this project a concise and coherent plan of action will be developed in consultation with the CDC staff. The Department of Epidemiology will provide expertise relevant to the methodological and analytical issues. Several consultants from Michigan Department of Community Health, Research Triangle Institute, and the University of North Carolina -Chapel Hill have agreed to to provide their expertise on various aspects of this project.