Clinical Center: Parkinson's Disease Neuroprotection

描述（由申请人提供）：该项目的目的是进行初步研究，以确定帕金森病的神经保护药物，并在随机双盲临床试验中令人信服地证明一种或多种药物对减缓帕金森病进展的功效，并确定这些药物的毒性和耐受性。我们的临床研究中心将是一个由三个地方站点组成的联合体，每个站点都有进行帕金森病临床试验的历史和兴趣。牵头的地点将是托马斯·杰斐逊大学（帕金森氏病研究单位），在宾夕法尼亚州布林莫尔的干线健康医院和宾夕法尼亚州威尔明顿的神经病学协会设有卫星站点。该联盟横跨费城大都市区，人口稠密的费城西北郊区，宾夕法尼亚州东南部，南新泽西和整个特拉华州将大大提高我们参与的任何研究项目招募患者的能力。该联盟的优势在于参与者的集体研究专业知识，以及由此增加的早期帕金森病患者的可用性。由于这个联盟，我们有信心我们将能够超过最低招募患者数量约50%进入研究。该临床中心的每个组成部分都由在帕金森病患者的临床和研究评估方面经验丰富的临床人员以及在招募和留住帕金森病患者以及临床方案管理方面经验丰富的护士和临床协调员组成。

DESCRIPTION (provided by applicant): The objective of this project is to perform pilot studies to identify putative neuroprotective agents for Parkinson's disease and to demonstrate convincingly in a randomized, double-blind clinical trial the efficacy of one or more pharmacological agents for slowing the progression of Parkinson's disease and to determine the toxicity and tolerability of these agents.Our Clinical Research Center will be a consortium of three local sites, each with a history and interest in conducting Parkinson's disease clinical trials. The lead site will be Thomas Jefferson University (Parkinson's Disease Research Unit), with satellite sites at Main Line Health Hospitals in Bryn Mawr, PA and Neurology Associates, P.A. in Wilmington, DE. This consortium, spanning the Philadelphia metropolitan area, the heavily populated northwestern suburbs of Philadelphia, Southeast Pennsylvania, Southern New Jersey and the entire state of Delaware will greatly enhance our ability to enroll patients in any research project in which we participate. The strength of this consortium is the collective research expertise of the participants and the resultant enhanced availability of early Parkinson's disease patients. As a result of this consortium, we are confident that we will be able to exceed the minimum number of patients to be recruited into study by approximately 50%. Each component of this Clinical Center is staffed by clinical personnel experienced in the clinical and research assessment of Parkinson's disease patients and by accomplished nurses and clinical coordinators with experience in the recruitment and retention of Parkinson's disease patients and the administration of clinical protocols.