Clinical Center: Parkinson's Disease Neuroprotection

描述（申请人提供）：本项目的目的是进行试点研究，以确定帕金森病的假定神经保护剂，并在一个随机，表示“双”之义我们的临床研究中心将是一个由以下人员组成的联盟：三个当地网站，每个网站都有进行帕金森病临床试验的历史和兴趣。牵头研究中心将是托马斯杰斐逊大学（帕金森病研究中心），卫星研究中心位于宾夕法尼亚州布林莫尔的干线卫生医院和宾夕法尼亚州神经病学协会。在特拉华州的威尔明顿。这个联盟横跨费城大都市区、人口稠密的费城西北郊区、宾夕法尼亚州东南部、新泽西南部和整个特拉华州，将大大提高我们在参与的任何研究项目中招募患者的能力。该联盟的优势在于参与者的集体研究专业知识以及由此产生的早期帕金森病患者的可用性增强。由于该联盟，我们相信我们将能够超过研究招募的最低患者数量约50%。该临床中心的每个组成部分都配备了在帕金森病患者的临床和研究评估方面经验丰富的临床人员，以及在招募和保留帕金森病患者以及管理临床方案方面经验丰富的护士和临床协调员。

DESCRIPTION (provided by applicant): The objective of this project is to perform pilot studies to identify putative neuroprotective agents for Parkinson's disease and to demonstrate convincingly in a randomized, double-blind clinical trial the efficacy of one or more pharmacological agents for slowing the progression of Parkinson's disease and to determine the toxicity and tolerability of these agents.Our Clinical Research Center will be a consortium of three local sites, each with a history and interest in conducting Parkinson's disease clinical trials. The lead site will be Thomas Jefferson University (Parkinson's Disease Research Unit), with satellite sites at Main Line Health Hospitals in Bryn Mawr, PA and Neurology Associates, P.A. in Wilmington, DE. This consortium, spanning the Philadelphia metropolitan area, the heavily populated northwestern suburbs of Philadelphia, Southeast Pennsylvania, Southern New Jersey and the entire state of Delaware will greatly enhance our ability to enroll patients in any research project in which we participate. The strength of this consortium is the collective research expertise of the participants and the resultant enhanced availability of early Parkinson's disease patients. As a result of this consortium, we are confident that we will be able to exceed the minimum number of patients to be recruited into study by approximately 50%. Each component of this Clinical Center is staffed by clinical personnel experienced in the clinical and research assessment of Parkinson's disease patients and by accomplished nurses and clinical coordinators with experience in the recruitment and retention of Parkinson's disease patients and the administration of clinical protocols.